AI Article Synopsis
- Distinct modifications of jasmonic acid (JA) regulate plant growth and immunity, with hydroxylated JA (12OH-JA) promoting certain plant developments while inhibiting defense mechanisms.
- The study identifies an enzyme, antibiotic biosynthesis monooxygenase (Abm), that converts JA into 12OH-JA in the rice blast fungus, aiding the fungus in evading plant defenses upon invasion.
- Loss of Abm in the fungus results in increased plant defense responses, while 12OH-JA can dampen these responses, highlighting the dynamic interaction between plants and pathogens and revealing potential antifungal targets.
Article Abstract
Distinct modifications fine-tune the activity of jasmonic acid (JA) in regulating plant growth and immunity. Hydroxylated JA (12OH-JA) promotes flower and tuber development but prevents induction of JA signaling, plant defense or both. However, biosynthesis of 12OH-JA has remained elusive. We report here an antibiotic biosynthesis monooxygenase (Abm) that converts endogenous free JA into 12OH-JA in the model rice blast fungus Magnaporthe oryzae. Such fungal 12OH-JA is secreted during host penetration and helps evade the defense response. Loss of Abm in M. oryzae led to accumulation of methyl JA (MeJA), which induces host defense and blocks invasive growth. Exogenously added 12OH-JA markedly attenuated abmΔ-induced immunity in rice. Notably, Abm itself is secreted after invasion and most likely converts plant JA into 12OH-JA to facilitate host colonization. This study sheds light on the chemical arms race during plant-pathogen interaction, reveals Abm as an antifungal target and outlines a synthetic strategy for transformation of a versatile small-molecule phytohormone.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/nchembio.1885 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Botrytis cinerea-induced F-box protein 1 enhances disease resistance by inhibiting JAO/JOX-mediated jasmonic acid catabolism in Arabidopsis.
Mol Plant
February 2024
The Key Laboratory of Plant Development and Environmental Adaptation Biology, Ministry of Education, School of Life Sciences, Shandong University, Qingdao 266237, China. Electronic address:
Jasmonic acid (JA) is a crucial phytohormone that regulates plant immunity. The endogenous JA level is determined by the rates of its biosynthesis and catabolism in plants. The activation of JA biosynthesis has been well documented; however, how plants repress JA catabolism upon pathogen infection remains elusive.
View Article and Find Full Text PDFAtGH3.10 is another jasmonic acid-amido synthetase in Arabidopsis thaliana.
Plant J
May 2022
Division of Biological Science, Nara Institute of Science and Technology (NAIST), Ikoma, Japan, 630-0192.
Jasmonoyl-isoleucine (JA-Ile) is a key signaling molecule that activates jasmonate-regulated flower development and the wound stress response. For years, JASMONATE RESISTANT1 (JAR1) has been the sole jasmonoyl-amino acid synthetase known to conjugate jasmonic acid (JA) to isoleucine, and the source of persisting JA-Ile in jar1 knockout mutants has remained elusive until now. Here we demonstrate through recombinant enzyme assays and loss-of-function mutant analyses that AtGH3.
View Article and Find Full Text PDFJA-Ile-macrolactone 5b Induces Tea Plant () Resistance to Both Herbivore and Pathogen .
Int J Mol Sci
March 2020
Tea Research Institute, Chinese Academy of Agricultural Sciences, Hangzhou 310008, China.
Jasmonates (JAs), the group of lipid-derived hormones, were found to control the defense responses in a myriad of plants. Meaningfully, the macrolactones of 12-hydroxy jasmonate isoleucine (12OH-JA-Ile) were reported to induce the defensive response of wild tobacco. However, little to nothing has been known about the elicitation effect of JA-Ile-macrolactones on woody plants to harmful organisms, let alone its underlying mechanisms.
View Article and Find Full Text PDF12-Hydroxy-Jasmonoyl-l-Isoleucine Is an Active Jasmonate That Signals through CORONATINE INSENSITIVE 1 and Contributes to the Wound Response in Arabidopsis.
Plant Cell Physiol
October 2019
Department of Biochemistry, University of Missouri, Columbia, MO, USA.
12-hydroxy-jasmonoyl-isoleucine (12OH-JA-Ile) is a metabolite in the catabolic pathway of the plant hormone jasmonate, and is synthesized by the cytochrome P450 subclade 94 enzymes. Contrary to the well-established function of jasmonoyl-isoleucine (JA-Ile) as the endogenous bioactive form of jasmonate, the function of 12OH-JA-Ile is unclear. Here, the potential role of 12OH-JA-Ile in jasmonate signaling and wound response was investigated.
View Article and Find Full Text PDFTasselseed5 encodes a cytochrome C oxidase that functions in sex determination by affecting jasmonate catabolism in maize.
J Integr Plant Biol
February 2020
National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200032, China.
Maize (Zea mays L.) is a monoecious grass plant in which mature male and female florets form the tassel and ear, respectively. Maize is often used as a model plant to study flower development.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!