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Generation of novel lipid metabolism-based signatures to predict prognosis and immunotherapy response for colorectal adenocarcinoma.
Sci Rep
July 2024
Department of General Surgery, The Fourth Affiliated Hospital of Soochow University, Suzhou, 215127, China.
Lipid metabolism reprogramming involves in epithelial-mesenchymal transition (EMT), cancer stemness and immune checkpoints (ICs), which influence the metastasis of cancer. This study aimed to generate lipid metabolism-based signatures to predict prognosis, immunotherapy and chemotherapy response for colorectal adenocarcinoma (COAD). Transcriptome data and clinical information of COAD patients were collected from the cancer genome atlas (TCGA) database.
View Article and Find Full Text PDFThe Spinocerebellar Ataxia 34-Causing W246G ELOVL4 Mutation Does Not Alter Cerebellar Neuron Populations in a Rat Model.
Cerebellum
October 2024
Department of Cell Biology, University of Oklahoma Health Sciences Center, 940 S.L. Young Blvd, BMSB-100, Oklahoma City, OK, 73104, United States of America.
Spinocerebellar ataxia 34 (SCA34) is an autosomal dominant disease that arises from point mutations in the fatty acid elongase, Elongation of Very Long Chain Fatty Acids 4 (ELOVL4), which is essential for the synthesis of Very Long Chain-Saturated Fatty Acids (VLC-SFA) and Very Long Chain-Polyunsaturated Fatty Acids (VLC-PUFA) (28-34 carbons long). SCA34 is considered a neurodegenerative disease. However, a novel rat model of SCA34 (SCA34-KI rat) with knock-in of the W246G ELOVL4 mutation that causes human SCA34 shows early motor impairment and aberrant synaptic transmission and plasticity without overt neurodegeneration.
View Article and Find Full Text PDFPotential Clinical Benefit of Very Long Chain Fatty Acid Supplementation in Spinocerebellar Ataxia Type 34.
Cerebellum
October 2024
Department of Neurology, Hospital Universitario Marqués de Valdecilla (IDIVAL), University of Cantabria, CIBERNED, Avenida de Valdecilla s/n, Santander, 39008, Spain.
Article Synopsis
- - Spinocerebellar ataxia type 34 (SCA34) is a genetic disorder that leads to late-onset coordination issues and skin lesions, caused by mutations in the ELOVL4 gene, which is crucial for producing certain fatty acids important for brain health.
- - Research indicates that SCA34 patients may have lower levels of important fatty acids (C28, C30, C32, C34, and C36) and show myelin damage in the brain, potentially linked to the ELOVL4 mutations.
- - The authors propose that measuring specific fatty acid levels could help identify deficiencies in SCA34, and suggest that treatment with these fatty acids might improve symptoms, similar to treatments used for other
Elovl4b knockout zebrafish as a model for ocular very-long-chain PUFA deficiency.
J Lipid Res
March 2024
Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, UT, USA; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT, USA. Electronic address:
Very-long-chain PUFAs (VLC-PUFAs) are a group of lipids with chain lengths >24 carbons, and the ELOVL4 (elongation of very-long-chain FA-4) enzyme is responsible for vertebrate VLC-PUFA biosynthesis. Studies on the role of VLC-PUFAs in vision have been hindered because of the need for adequate animal models to capture the global loss of VLC-PUFAs. Since homozygous Elovl4 ablation is lethal in neonatal mice because of catastrophic drying from the loss of their protective skin barrier, we established a zebrafish (Danio rerio) model of Elovl4 ablation.
View Article and Find Full Text PDFNovel Approaches for Elongation of Fish Oils into Very-Long-Chain Polyunsaturated Fatty Acids and Their Enzymatic Interesterification into Glycerolipids.
J Agric Food Chem
November 2023
Department of Dairy, Fat and Cosmetics, Faculty of Food and Biochemical Technology, University of Chemistry and Technology, Technická 3, 166 28 Prague, Czechia.
Elongation of the Very-Long-Chain Fatty Acids-4 (ELOVL4) enzyme that is expressed in neuronal tissues, sperm, and testes mediates biosynthesis of very-long-chain polyunsaturated fatty acids (VLC-PUFAs) from dietary long chain PUFAs (LC-PUFAs). The VLC-PUFAs are critical for neuronal and reproductive function. Therefore, mutations in ELOVL4 that affect VLC-PUFA biosynthesis contribute to retinal degenerative diseases including Autosomal Dominant Stargardt-like Macular Dystrophy (STGD3).
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