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Bilateral cytomegalovirus retinitis as the presenting feature of Dyskeratosis Congenita.
Eur J Ophthalmol
May 2023
Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh-160012, India.
Purpose: To describe a young male with bilateral sequential Cytomegalovirus retinitis (CMVR) as the presenting feature of Dyskeratosis Congenita.
Case Report: A 25-year-old human immunodeficiency virus (HIV) negative male developed CMVR in his left eye, while on a three week course of oral valganciclovir therapy for CMV retinitis in his right eye. Systemic examination revealed reticular hypopigmentation of the forearms, dystrophic nails, oral leukoplakia and complete blood counts showed pancytopenia.
Histopathological characteristics and CD163 immunostaining pattern in fibrous papule of the face.
J Cutan Pathol
February 2021
Department of Pathology, Acıbadem University School of Medicine, Istanbul, Turkey.
Article Synopsis
- The study focuses on the inflammatory characteristics observed in fibrous papule (FP), an often-overlooked skin condition, highlighting the presence of inflammation, pagetoid dyskeratosis, and the usefulness of CD163 immunohistochemistry as a diagnostic tool.
- Researchers analyzed skin biopsy samples of 32 confirmed FP cases for various inflammatory parameters as well as the presence of specific staining patterns in the cells.
- The findings revealed a high incidence of inflammation in these cases, with approximately 25% showing pagetoid dyskeratosis, and all samples exhibiting prominent CD163 staining, suggesting a potential inflammatory response linked to FP.
Focal acantholytic dyskeratosis: a multifocal verrucous presentation in the oral cavity.
Int J Dermatol
January 2021
Oral Pathology and Medicine Unit, Department of Stomatology II, University of the Basque Country/EHU, Leioa, Spain.
Thyroxine restores severely impaired cutaneous re-epithelialisation and angiogenesis in a novel preclinical assay for studying human skin wound healing under "pathological" conditions ex vivo.
Arch Dermatol Res
April 2021
Centre for Dermatology Research, University of Manchester and NIHR Manchester Biomedical Research Centre, Manchester, UK.
Impaired cutaneous wound healing remains a major healthcare challenge. The enormity of this challenge is compounded by the lack of preclinical human skin wound healing models that recapitulate selected key factors underlying impaired healing, namely hypoxia/poor tissue perfusion, oxidative damage, defective innervation, and hyperglycaemia. Since organ-cultured human skin already represents a denervated and impaired perfusion state, we sought to further mimic "pathological" wound healing conditions by culturing experimentally wounded, healthy full-thickness frontotemporal skin from three healthy female subjects for three days in either serum-free supplemented Williams' E medium or in unsupplemented medium under "pathological" conditions (i.
View Article and Find Full Text PDFDarier Disease - A Clinical Illustration of Its High Variable Expressivity.
Cureus
December 2019
Otolaryngology, St. George's University School of Medicine, St. George's, GRD.
Darier disease (DD), also known as dyskeratosis follicularis, is a rare genodermatosis classically characterized by persistent hyperkeratotic papules and plaques affecting the seborrheic areas. Due to its variable expressivity, it can present with very discrete clinical features for many years, leading to diagnostic errors and incorrect treatments. We report an unusual case of Darier disease in a 69-year-old male patient in which the classical features of DD had a remarkably late onset.
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