AI Article Synopsis
- Ferulic acid-based polymers using ethylene glycol linkers were developed to enhance the release rate of ferulic acid for skin care applications, addressing the limitations of slower release rates seen in previous polymers.
- Characterization techniques like nuclear magnetic resonance and Fourier transform infrared spectroscopy confirmed the polymers' chemical structure and properties, revealing that increasing linker length decreases the glass transition temperature while higher oxygen content lowers contact angles.
- The study found that these polymers efficiently release ferulic acid without degrading its bioactivity, making them suitable for use in topical formulations.
Article Abstract
Ferulic acid-based polymers with aliphatic linkages have been previously synthesized via solution polymerization methods, yet they feature relatively slow ferulic acid release rates (∼11 months to 100% completion). To achieve a more rapid release rate as required in skin care formulations, ferulic acid-based polymers with ethylene glycol linkers were prepared to increase hydrophilicity and, in turn, increase ferulic acid release rates. The polymers were characterized using nuclear magnetic resonance and Fourier transform infrared spectroscopies to confirm chemical composition. The molecular weights, thermal properties (e.g., glass transition temperature), and contact angles were also obtained and the polymers compared. Polymer glass transition temperature was observed to decrease with increasing linker molecule length, whereas increasing oxygen content decreased polymer contact angle. The polymers' chemical structures and physical properties were shown to influence ferulic acid release rates and antioxidant activity. In all polymers, ferulic acid release was achieved with no bioactive decomposition. These polymers demonstrate the ability to strategically release ferulic acid at rates and concentrations relevant for topical applications such as skin care products.
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| http://dx.doi.org/10.1021/acs.biomac.5b00824 | DOI Listing |
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