AI Article Synopsis
- Lysozyme, an antimicrobial peptide found in mammalian skin, is expressed in hair follicles, but its role in hair growth has not been clearly established.
- In a study with mouse vibrissae follicles, treatment with lysozyme (at 1-10μg/ml) showed that it is mainly located in the dermal papilla and dermal sheath areas.
- The results indicated that lysozyme enhanced hair growth by promoting shaft production and increasing the proliferation of keratinocytes and key growth factors in dermal papilla cells.
Article Abstract
Lysozyme is a well-known antimicrobial peptide that exists widely in mammalian skin and it is also expressed by pilosebaceous units. However, the exact location of lysozyme in hair follicles and whether it exerts any direct effects on hair follicle growth are unclear. To determine whether lysozyme affected hair growth in vitro, micro-dissected mouse vibrissae follicles (VFs) were treated in serum-free organ culture for 3 days with lysozyme (1-10μg/ml). After that, the effects of lysozyme on dermal papilla (DP) cells were also investigated. Lysozyme was mainly identified in DP and dermal sheath regions of VF by immunochemistry. In addition, 5-10μg/ml lysozyme had a promoting effect on shaft production. It was also associated with significant proliferation of matrix keratinocytes by immunofluorescence observation. Furthermore, lysozyme promoted hair growth by increasing the levels of alkaline phosphatase and lymphoid enhancer factor 1 in DP, as determined by Western blotting. These results indicate that lysozyme is a promoter of VF growth via enhancing the hair-inductive capacity of DP cells during organ culture.
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| http://dx.doi.org/10.1016/j.acthis.2015.07.005 | DOI Listing |
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