AI Article Synopsis
- The study investigates the relationship between TAS2R38 gene haplotypes and alcohol consumption in the Mexican-Mestizo population, identifying two main haplotypes: AVV and PAI.
- The research involved genotyping 375 individuals to analyze their haplotypes and found that those with the AVV homozygous genotype were significantly more likely to be drinkers compared to nondrinkers.
- The results suggest that the high frequency of the AVV haplotype may contribute to a greater preference for alcohol in this population.
Article Abstract
Background: Alcohol intake has been associated with the bitter taste receptor T2R38. TAS2R38 gene expresses two common haplotypes: PAV and AVI. It has been reported that AVI homozygotes consume more alcohol than heterozygotes and PAV homozygotes. The aim of this study was to determine the prevalence of the TAS2R38 haplotypes among Mexican-Mestizo population and to analyze its association with alcohol intake.
Material And Methods: In a cross-sectional study, a total of 375 unrelated Mestizo individuals were genotyped for TAS2R38 polymorphisms (A49P, V262A and I296V) by a Real-Time PCR System (TaqMan). Haplotype frequencies were calculated. Association of TAS2R38 haplotypes with alcohol intake was estimated in drinkers (DRS) and nondrinkers (NDRS).
Results: Two haplotypes accounted for over 96% of all haplotypes(AVV, 60%, and PAI, 36.5%). The frequency of AVV homozygotes was significantly higher in DRS than NDRS(47.2 vs. 32.2%, respectively; p < 0.05). Additionally, the AVV/AVV genotype was associated with alcohol intake when compared with heterozygotes and PAI homozygotes (OR = 1.79, 95% CI 1.13-2.84, p < 0.05 and OR = 2.23, 95% CI 1.11-4.48; p < 0.05, respectively).
Conclusions: In conclusion, two TAS2R38 haplotypes(AVV and PAI) prevailed in Mexican-Mestizo population. The novel AVV haplotype was associated with alcohol intake. The high prevalence of this allelic profile in our population could help to explain, at least in part, the preference for alcohol among the Mexicans.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
[Alcohol consumption and incidence of abdominal obesity in participants of the ELSA-Brasil cohort after nine years of follow-up].
Cien Saude Colet
January 2025
Universidade Federal do Espírito Santo. Vitória ES Brasil.
The scope of this article is to analyze the correlation between alcohol consumption and abdominal obesity in participants of the ELSA-Brasil cohort after a follow-up period of nine years. A longitudinal analysis was performed with baseline and follow-up data from ELSA-Brasil. At baseline, 15,105 civil servants were enrolled.
View Article and Find Full Text PDFThe eyes have it: Alcohol-induced eye movement impairment and perceived impairment in older adults with and without alcohol use disorder.
Alcohol Clin Exp Res (Hoboken)
January 2025
Department of Psychiatry & Behavioral Neuroscience, University of Chicago, Chicago, Illinois, USA.
Background: While alcohol has been shown to impair eye movements in young adults, little is known about alcohol-induced oculomotor impairment in older adults with longer histories of alcohol use. Here, we examined whether older adults with chronic alcohol use disorder (AUD) exhibit more acute tolerance than age-matched light drinkers (LD), evidenced by less alcohol-induced oculomotor impairment and perceived impairment.
Method: Two random-order, double-blinded laboratory sessions with administration of alcohol (0.
Elevated Platelet-to-Lymphocyte Ratio as a Predictor of All-Cause and Cardiovascular Mortality in Hypertensive Individuals.
J Clin Hypertens (Greenwich)
January 2025
Department of Cardiology, Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.
The platelet-to-lymphocyte ratio (PLR) has been proposed as a promising inflammatory biomarker, with potential implications for cardiovascular prognosis. However, its association with mortality outcomes in hypertensive individuals is not fully elucidated. This investigation sought to clarify the linkage between PLR and both overall and cardiovascular mortality in hypertensive individuals.
View Article and Find Full Text PDFHeart Failure in Atrial Fibrillation Subtypes in Women and Men in the Tromsø Study.
JACC Adv
February 2025
Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway.
Background: Atrial fibrillation (AF) and heart failure (HF) often coexist and impact morbidity and mortality. There is limited knowledge on the association of AF subtypes with HF according to sex.
Objectives: The purpose of this study was to explore sex-specific associations between AF subtypes and subsequent HF, identifying HF risk factors in participants with AF, and exploring the combined impact on mortality.
COVID-19 Stress is Associated with Increased Smoking among People with HIV in Western Washington: A Cross-Sectional Survey.
COVID
October 2024
Department of Epidemiology, University of Washington, Seattle, WA, USA.
Background: People living with HIV (PWH) frequently have co-morbid substance use disorders that may have been impacted by the COVID-19 pandemic. This study examined associations between COVID-related stress and increased substance use among PWH in Washington State.
Methods: Between August 2020 and March 2021, we conducted an online survey of 397 PWH in Western Washington.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!