AI Article Synopsis
- Lactoferrin (LF) is a protein in milk known for its anti-inflammatory properties, which were explored in the context of LPS-induced endometritis in mice.
- * In the study, LF was administered before and after LPS induction, showing significant reduction in uterine damage and inflammation markers.
- * The findings indicate that LF may serve as a potential treatment for endometritis due to its ability to mitigate inflammatory responses.
Article Abstract
Lactoferrin (LF) is one of the most abundant proteins found in milk, and it has been reported to have anti-inflammatory properties. However, the anti-inflammatory effects of LF on lipopolysaccharide (LPS)-induced endometritis and the underlying molecular mechanisms remain to be elucidated. In this study, we evaluated the effects of LF on LPS-induced endometritis in mice. The endometritis model was established by the perfusion of mice with LPS. LF was administered by intraperitoneal injection 1h before and 12h after LPS induction. Our results demonstrated that LF significantly attenuated the histopathological changes in the uterus, reduced the activity of myeloperoxidase (MPO) and the levels of nitric oxide (NO), and inhibited the activation of NF-κB and the expression of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) in a dose-dependent manner. The results suggest that LF has an anti-inflammatory effect on LPS-induced endometritis in mice. Therefore, LF may be a potential therapeutic agent for the treatment of endometritis.
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| http://dx.doi.org/10.1016/j.intimp.2015.07.040 | DOI Listing |
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