AI Article Synopsis
- * Adding a correct copy of the bldA gene helped restore sporulation and led to the creation of new natural products.
- * In our research, we examined bldA expression in various poorly sporulating Streptomyces strains, finding new compounds in 7 out of 15 strains and isolating two new compounds for structural analysis.
Article Abstract
Recently we described an unusual way of activating a cryptic gene cluster when we explored the origin of the bald phenotype of Streptomyces calvus. Complementation of S. calvus with a correct copy of bldA restored sporulation and additionally promoted production of a new natural products. In this study we report on the expression of bldA in several Streptomyces strains that have been described as "poorly sporulating" strains. In seven out of 15 cases, HPLC profiling revealed the production of new compounds, and in two cases the overproduction of known compounds. Two compounds were isolated and their structures were determined.
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| http://dx.doi.org/10.1002/cbic.201500297 | DOI Listing |
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