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Ticked Off: A Case of Disappearing Cell Lines.
Cureus
November 2024
Internal Medicine, Weiss Memorial Hospital, Chicago, USA.
Human granulocytic anaplasmosis (HGA) is transmitted by the black-legged tick and presents with fever, thrombocytopenia, leukocytopenia, and elevated transaminases. If left untreated, HGA can progress to hemophagocytic lymphohistiocytosis (HLH), which can be fatal. Here, we discuss a case of a woman diagnosed with anaplasmosis who was treated promptly.
View Article and Find Full Text PDFThe overlooked burden of persistent physical symptoms: a call for action in European healthcare.
Lancet Reg Health Eur
January 2025
Department of Psychosomatic Medicine and Psychotherapy, Centre for Internal Medicine, University Medical Centre Hamburg-Eppendorf, Martinistraße 52, Hamburg 20246, Germany.
Regardless of their cause, persistent physical symptoms are distressing somatic complaints that occur on most days for at least several months. They are common in patients with somatic diseases, functional somatic disorders, mental disorders, and undiagnosed medical conditions and are often associated with significant impairment and medical costs. Despite their prevalence and impact, persistent physical symptoms are often overlooked in medical care.
View Article and Find Full Text PDFA sex-based analysis of complete blood count features during acute, untreated Lyme disease.
Front Med (Lausanne)
October 2024
Lyme Disease Research Center, Division of Rheumatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Introduction: Although lymphopenia has been described in acute Lyme disease (LD), the complete blood count (CBC) has not been comprehensively examined, nor have sex-based analyses been conducted. We analyzed CBC values and identified sex-based trends among patients with early LD by comparing both to controls without a history of LD and to patients' pre-morbid values.
Methods: We enrolled participants from the Mid-Atlantic US with diagnostic erythema migrans and controls with no history of LD.
Evaluation of the Epitogen Lyme Detect IgG ELISA: a novel peptide multiplexing approach.
Microbiol Spectr
October 2024
EpitogenX Ltd, Foresterhill Health Campus, Aberdeen, United Kingdom.
Article Synopsis
- Lyme Borreliosis (LB), or Lyme disease, is increasingly concerning due to its severe health risks from untreated cases, often diagnosed too late with current tests having low sensitivity.
- A new diagnostic test, the Epitogen Lyme Detect IgG ELISA, was validated in this study using 220 serum samples to assess sensitivity and specificity against the standard LIAISON Borrelia IgG test.
- The Epitogen test showed comparable performance for late stages of LB and significantly higher sensitivity for early suspected cases, indicating it could improve early and accurate diagnosis of Lyme disease.
When it rains, it pours: Early treatment with tecovirimat of cardiac complications associated with monkeypox infection in a person with HIV and previously undiagnosed Lyme disease. A case report.
Heliyon
January 2024
Intermediate Care Unit, Careggi University Hospital, Florence, Italy.
Cardiac involvement, such as myocarditis and pericarditis, can be a severe complication of monkeypox virus (mpox) infection and could be related to other co-infections with cardiac involvement. Tecovirimat is an antiviral specifically designed to inhibit smallpox infection diffusion and approved by the FDA for other Orthopoxvirus infections; its efficacy in mpox-infected patients is not well established. We present the case of a cardiac complication during mpox infection in a previously undiagnosed Lyme disease in a 42-year-old man living with HIV.
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