AI Article Synopsis
- Osteoclasts are large, multinucleated cells essential for bone absorption and derived from specific stem cells, playing a crucial role in bone metabolism regulation.
- The process of osteoclast formation and maturation involves complex regulatory mechanisms, notably the OPG/RANKL/RANK system.
- Recent research has uncovered a close relationship between immune cells and osteoclasts in bone metabolism, suggesting new treatment avenues for bone diseases, although the apoptosis mechanism of osteoclasts remains poorly understood and requires further study.
Article Abstract
Osteoclasts are multinucleated giant cell, which derived from mononuclear myeloid hematopoietic stem cells with the function of bone absorption. Osteoclasts plays a key role in bone metabolism, therefore the body is very strict to regulation of osteoclastogenesis. Mobilization and differentiation of osteoclast maturation is a complex and sophisticated multi-level regulatory processes. In the relevant regulatory mechanisms, OPG/RANKL/RANK system plays a pivotal role in the process of osteoclast differentiation and maturation. Recent studies revealed that immune cells and osteoclasts were closely connect with each other in the field of bone metabolism, also provide a new therapeutic target for the treatment of bone diseases. The apoptosis of osteoclasts in bone metabolism have been payed more attention,while its mechanism is still not clear, which need further research.
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