Xanthoma is a lesion most commonly seen in soft tissues such as the skin, subcutis, or tendon sheaths. Xanthoma formation is often associated with primary or secondary hyperlipidemia. Primary bone xanthomas are extremely rare benign bone lesions not associated with hyperlipidemia, histopathologically characterized by histiocytes, abundant lipid containing macrophages (foam cells), and multinucleated giant cells. Cholesterol clefts can be found in the medullary bone. Less than ten cases of xanthoma in the mandible have been reported. We present a rare primary intrabony xanthoma in a normolipidemic patient.
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http://dx.doi.org/10.1007/s12105-015-0643-z | DOI Listing |
J Med Case Rep
May 2024
Department of Special Surgery, Medical Faculty, Medical University of Plovdiv, Plovdiv, Bulgaria.
Background: A xanthoma is a rare bone condition consisting of a predominant collection of lipid-rich, foamy histiocytes. The central xanthoma of the jaws is a unique benign tumor.
Case Report: A 15-year-old Caucasian male has been presented to our department.
Head Neck Pathol
March 2024
University of Mississippi Medical Center, 2500 N. State St, Jackson, MS, 39216-4505, USA.
Background: Intraosseous xanthomas are rare benign lesions sometimes associated with excess lipid production. Xanthoma of the jaw bones (XJB) was first reported in 1964, and fewer than 50 cases have been reported in the English literature to date. The etiopathogenesis of XJB is highly suggestive of a reactive process or a metabolic condition.
View Article and Find Full Text PDFOral Surg Oral Med Oral Pathol Oral Radiol
August 2023
Head and Neck Pathology, The Joint Pathology Center, Silver Spring, MD.
Objective: Intra-osseous fibrohistiocytic lesions have long been reported in the literature; evidence suggests they represent a heterogeneous group of reactive and neoplastic processes. This study evaluated a series of gnathic fibrohistiocytic lesions to identify and categorize their clinical, radiographic and morphologic spectrum.
Study Design: A retrospective case search over 48 years was conducted for maxillary and mandibular intra-bony fibrohistiocytic lesions.
Imaging Sci Dent
June 2022
Department of Oral and Maxillofacial Surgery, National Health Insurance Service Ilsan Hospital, Goyang, Korea.
Intraosseous xanthoma of the mandible is a rare benign disorder. A 17-year-old male patient presented with a suspected abscess in the right mandibular third molar, detected on a panoramic radiograph. The patient had no history of systemic or lipid-related metabolic diseases and complained of no specific symptoms or pain.
View Article and Find Full Text PDFWorld Neurosurg
August 2020
Division of Neurosurgery, Department of Surgery, Khoo Teach Puat Hospital, Singapore.
Background: Xanthomas are benign lipomatous deposits that can be found systemically in various tissues including bones. Their presence in the skull remains a rare entity. Despite their benign characteristics, imaging modalities are often unable to distinguish them from malignant lesions.
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