AI Article Synopsis
- The study explores how copper(II) ions can change the shape of i-motif DNA from its usual form to a hairpin structure.
- Unlike past methods that required pH changes to fold the DNA, this approach uses metal ions.
- The transformation is reversible, meaning the hairpin structure can go back to its original form when treated with EDTA, a chelating agent.
Article Abstract
i-Motif DNA structures have previously been utilised for many different nanotechnological applications, but all have used changes in pH to fold the DNA. Herein we describe how copper(II) cations can alter the conformation of i-motif DNA into an alternative hairpin structure which is reversible by chelation with EDTA.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563791 | PMC |
| http://dx.doi.org/10.1039/c5cc05111h | DOI Listing |
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