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Genetic Association Between NFKBIA -881A>G Polymorphism and Cancer Susceptibility. | LitMetric

AI Article Synopsis

  • - Several studies have looked into the -881 A>G polymorphism in the NFKBIA gene and its potential link to cancer, but results have been inconsistent.
  • - This study reviewed data from 5 case-control studies involving nearly 4,700 participants to explore the relationship between the polymorphism and cancer risk, using various statistical models.
  • - Results showed no overall cancer risk association; however, there was a significant link in Asian populations, suggesting that the -881 A>G polymorphism may be a factor in cancer susceptibility among these groups.

Article Abstract

Several epidemiological studies have focused on the role of nuclear factor-kappa-B inhibitor-alpha (NFKBIA) -881 A>G polymorphism in cancer susceptibility. However, the published data have led to contentious results. This study was designed to examine the association between -881 A>G polymorphism and cancer risk.Comprehensive search of PubMed, Web of science and Embase, identified a total of 5 case-control studies. To assess the association, comparison among all subjects plus subgroup analysis by ethnicity was performed and odds ratio (OR) along with 95% confidence interval (CI) was calculated with the fixed-effect model or the random-effects model dependent on the heterogeneity.The pooling data consisting of 1965 cancer cases and 2717 cancer-free controls demonstrated no significant association with overall cancer risk. However, the subgroup of Asian populations showed statistical evidence for an increase in risk of cancer (GG vs. AA, OR, 2.14; 95% CI, 1.03-4.46; GG + GA vs. AA, OR, 1.22; 95% CI, 1.01-1.47; GG vs. GA + AA, OR, 2.09; 95% CI, 1.01-4.34).This investigation on the association of -881 A>G polymorphism and cancer susceptibility reveals that -881 A>G polymorphism may act as a candidate for cancer development in Asian populations.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616602PMC
http://dx.doi.org/10.1097/MD.0000000000001024DOI Listing

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