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| http://dx.doi.org/10.5173/ceju.2015.e98 | DOI Listing |
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NOMPC ion channel hinge forms a gating spring that initiates mechanosensation.
Nat Neurosci
January 2025
Department of Cellular Neurobiology, University of Göttingen, Göttingen, Germany.
The sensation of mechanical stimuli is initiated by elastic gating springs that pull open mechanosensory transduction channels. Searches for gating springs have focused on force-conveying protein tethers such as the amino-terminal ankyrin tether of the Drosophila mechanosensory transduction channel NOMPC. Here, by combining protein domain duplications with mechanical measurements, electrophysiology, molecular dynamics simulations and modeling, we identify the NOMPC gating-spring as the short linker between the ankyrin tether and the channel gate.
View Article and Find Full Text PDFAgent-based simulation of trust networks and opportunistic behaviours of hydraulic infrastructure project participants.
PLoS One
January 2025
College of Engineering and Physical Sciences, University of Birmingham, Birmingham, West Midlands, United Kingdom.
Opportunistic behaviour has become a research hotspot in hydraulic infrastructure project management owing to its serious damage to the cooperation efficiency of all participants in a project. The trust networks formed by each participant can restrain opportunistic behaviour, but due to the dynamic evolution of the networks, its research should adopt a dynamic paradigm. The structure and evolution of trust networks can be simulated using computer simulations and modelling.
View Article and Find Full Text PDFBeyond Fang's fury: a computational study of the enzyme-membrane interaction and catalytic pathway of the snake venom phospholipase A toxin.
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LAQV/Requimte, Departamento de Química e Bioquímica, Faculdade de Ciências da Universidade do Porto Rua do Campo Alegre, s/n 4169-007 Porto Portugal
Snake venom-secreted phospholipases A (svPLAs) are critical, highly toxic enzymes present in almost all snake venoms. Upon snakebite envenomation, svPLAs hydrolyze cell membrane phospholipids and induce pathological effects such as paralysis, myonecrosis, inflammation, or pain. Despite its central importance in envenomation, the chemical mechanism of svPLAs is poorly understood, with detrimental consequences for the design of small-molecule snakebite antidotes, which is highly undesirable given the gravity of the epidemiological data that ranks snakebite as the deadliest neglected tropical disease.
View Article and Find Full Text PDFDistractor-specific control adaptation in multidimensional environments.
Nat Hum Behav
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Department of Psychological and Brain Sciences, Washington University in St. Louis, St Louis, MO, USA.
Goal-directed behaviour requires humans to constantly manage and switch between multiple, independent and conflicting sources of information. Conventional cognitive control tasks, however, only feature one task and one source of distraction. Therefore, it is unclear how control is allocated in multidimensional environments.
View Article and Find Full Text PDFThe Nordic-walking mechanism and its explanation of deconfined pseudocriticality from Wess-Zumino-Witten theory.
Nat Commun
January 2025
CP3-Origins, University of Southern Denmark, Odense, Denmark.
The understanding of phenomena falling outside the Ginzburg-Landau paradigm of phase transitions represents a key challenge in condensed matter physics. A famous class of examples is constituted by the putative deconfined quantum critical points between two symmetry-broken phases in layered quantum magnets, such as pressurised SrCu(BO). Experiments find a weak first-order transition, which simulations of relevant microscopic models can reproduce.
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