AI Article Synopsis
- Galectins are proteins that help cells respond to sugar molecules, with galectin-11 being a specific type found only in ruminants like sheep, goats, and cattle.
- Galectin-11 is vital for critical biological functions such as reproduction and immune responses against parasites, which are essential for sustainable livestock production.
- This study details the process of expressing, purifying, and crystallizing galectin-11 from domestic sheep, achieving high-resolution X-ray data to better understand its structure and function.
Article Abstract
Galectins are an evolutionarily conserved family of proteins that translate glycan recognition into cellular effects. Galectin-11 is a unique member of the galectin family that is only expressed in ruminants such as sheep, goat and cattle and that plays a critical role in several important biological processes, such as reproduction and parasite-mediated innate immune responses. Currently, these two areas are of major importance for the sustainability of ruminant livestock production. Despite the emerging biological significance of galectin-11, no structural information is available. It is expected that structural studies will unravel the functional mechanisms of galectin-11 activity. Here, the expression, purification and crystallization of the ruminant-specific galectin-11 from domestic sheep and the collection of X-ray data to 2.0 Å resolution are reported.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528930 | PMC |
| http://dx.doi.org/10.1107/S2053230X15010195 | DOI Listing |
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