AI Article Synopsis
- Many research groups are exploring new treatments for myocardial infarction, focusing on challenges like low success rates in cell therapy.
- Decellularized tissues, particularly when processed into powder, show promise for healing damaged tissues, maintaining beneficial properties.
- In a rat study, decellularized liver powder improved cell integration and blood vessel formation, which helped reduce heart tissue damage, indicating its potential use in treating heart attacks.
Article Abstract
Many research groups are currently investigating new treatment modalities for myocardial infarction. Numerous aspects need to be considered for the clinical application of these therapies, such as low cell integration and engraftment rates of cell injection techniques. Decellularized tissues are considered good materials for promoting regeneration of traumatic tissues. The properties of the decellularized tissues are sustained after processing to powder form. In this study, we examined the use of decellularized tissue powder in a rat model of acute myocardial infarction. The decellularized tissue powders, especially liver powder, promoted cell integration and neovascularization both in vitro and in vivo. Decellularized liver powder induced neovascularization in the infarct area, resulting in the suppression of myocardial necrosis. The results of this study suggest that decellularized liver powder has good potential for application as a blood supply material for the treatment of myocardial infarction.
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| http://dx.doi.org/10.1016/j.msec.2015.07.010 | DOI Listing |
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