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| http://dx.doi.org/10.1371/journal.ppat.1004992 | DOI Listing |
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Cytokine Storm in COVID-19: Exploring IL-6 Signaling and Cytokine-Microbiome Interactions as Emerging Therapeutic Approaches.
Int J Mol Sci
October 2024
Department of Infectious Diseases (Internal Medicine II), Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.
IL-6 remains a key molecule of the cytokine storms characterizing COVID-19, exerting both proinflammatory and anti-inflammatory effects. Emerging research underscores the significance of IL-6 trans-signaling over classical signaling pathways, which has shifted the focus of therapeutic strategies. Additionally, the synergistic action of TNF-α and IFN-γ has been found to induce inflammatory cell death through PANoptosis, further amplifying the severity of cytokine storms.
View Article and Find Full Text PDFVitamin D Receptor-Interplay in COVID-19-Negative, -Infected, and -Vaccinated Women during Pregnancy.
J Clin Med
October 2024
Department of Infectious Diseases, University of Medicine and Pharmacy "Lucian Blaga", 550169 Sibiu, Romania.
The trophoblast is a significant source of vitamin D synthesis during pregnancy, with the literature suggesting its role in fetal growth. We aim to underline a possible mechanism that would explain negative fetal outcomes in COVID-19-positive mothers by examining the relationship between altered placental structure and function and throphoblast cells' vitamin D receptor levels. The study included 170 placental samples collected from women who gave birth at term without complications, divided into three groups: COVID-19-positive and unvaccinated, COVID-19-negative and vaccinated, and COVID-19-negative and unvaccinated, with exclusion criteria for any other medical complications.
View Article and Find Full Text PDFMultidrug-Resistant Bacteria in Immunocompromised Patients.
Pharmaceuticals (Basel)
August 2024
Department of Preventive Medicine and Interdisciplinarity-Microbiology, University of Medicine and Pharmacy "Grigore T. Popa", 700115 Iasi, Romania.
The increasing incidence of antibiotic resistance in bacteria is a major problem in terms of therapeutic options, especially in immunocompromised patients, such as patients from intensive care units (ICUs), HIV-positive patients, patients with malignancies or transplant patients. Commensal bacteria, especially anaerobes, serve to maintain microbial stability by preventing overpopulation with pathogenic bacteria. In immunocompromised patients, microbiota imbalance caused by antibiotic therapy and decreased host immunity favors intestinal overpopulation with pathogenic species, leading to increased bacterial translocation and susceptibility to systemic infections.
View Article and Find Full Text PDFShedding Light on the COVID-19 Pandemic: Placental Expression of Cell Biomarkers in Negative, Vaccinated, and Positive Pregnant Women.
J Clin Med
September 2024
Department of Infectious Diseases, University of Medicine and Pharmacy "Lucian Blaga", 550169 Sibiu, Romania.
Article Synopsis
- The study examined markers of inflammation and placental development in relation to COVID-19's effects on pregnancy and fetal development.
- Researchers analyzed placental tissue from 170 women categorized into groups based on COVID status and vaccination.
- Findings showed that CD44, OPN, and COX-2 expressions varied by group, with significant alterations observed in those who were COVID-positive, indicating potential impacts on placental structure and function.
Multidisciplinary Teams in Musculoskeletal Infection - From a Pathologist's Perspective.
Pathol Res Pract
October 2024
Institute of Pathology, University of Regensburg, Regensburg, Germany; Institute of Pathology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. Electronic address:
Multidisciplinary team (MDT) meetings have emerged as a promising approach for the treatment of cancer patients. These meetings involve a team of healthcare professionals from different disciplines working together to develop a holistic, patient-centered treatment. Although MDT meetings are well established in oncology, they play a minor role in other diseases.
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