AI Article Synopsis
- Tumour lysis syndrome is characterized by elevated uric acid, phosphate, and potassium levels, alongside decreased calcium and impaired kidney function.
- Two children with T-cell acute lymphoblastic leukemia developed this syndrome due to high tumor loads.
- The administration of Sevelamer and Rasburicase successfully normalized serum phosphate levels in both patients within 24-48 hours, indicating Sevelamer's efficacy in treating hyperphosphatemia related to tumour lysis syndrome.
Article Abstract
Background: Tumour lysis syndrome is associated with high levels of uric acid, phosphate and potassium along with low levels of calcium and abnormal renal function. Sevelamer, an oral phosphate-binder is used in the treatment of hyperphosphatemia in children and adults on hemodialysis.
Case Characteristics: Two children with T-cell acute lymphoblastic leukemia who presented with a high tumour load and developed tumour lysis syndrome.
Observation: Both children received Rasburicase and Sevelamer hydrochloride. The serum phosphate reduced to normal levels within 24-48 hrs of initiation of sevelamer hydrochloride.
Message: Sevelamer appears to be an effective treatment for hyperphosphatemia associated with tumour lysis syndrome.
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| http://dx.doi.org/10.1007/s13312-015-0686-y | DOI Listing |
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