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Determination of the Negative Allosteric Binding Site of Cannabidiol at the CB1 Receptor: A Combined Computational and Site-Directed Mutagenesis Study.
ACS Chem Neurosci
January 2025
National Center for Natural Products Research, University of Mississippi, University, Mississippi 38677, United States.
Cannabinoid receptor 1 (CB1R) has been extensively studied as a potential therapeutic target for various conditions, including pain management, obesity, emesis, and metabolic syndrome. Unlike orthosteric agonists such as Δ-tetrahydrocannabinol (THC), cannabidiol (CBD) has been identified as a negative allosteric modulator (NAM) of CB1R, among its other pharmacological targets. Previous computational and structural studies have proposed various binding sites for CB1R NAMs.
View Article and Find Full Text PDFAutomatic 4D mitral valve segmentation from transesophageal echocardiography: a semi-supervised learning approach.
Med Biol Eng Comput
January 2025
Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milan, Italy.
Performing automatic and standardized 4D TEE segmentation and mitral valve analysis is challenging due to the limitations of echocardiography and the scarcity of manually annotated 4D images. This work proposes a semi-supervised training strategy using pseudo labelling for MV segmentation in 4D TEE; it employs a Teacher-Student framework to ensure reliable pseudo-label generation. 120 4D TEE recordings from 60 candidates for MV repair are used.
View Article and Find Full Text PDFSubmitral Pseudoaneurysm Repair and Posterior Leaflet Augmentation: Reoperative Mitral Valve Repair.
Ann Thorac Surg Short Rep
June 2024
Division of Cardiac Surgery, Department of Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania.
A 33-year-old woman who had previously undergone mitral valve repair for native valve endocarditis presented with a submitral left ventricular pseudoaneurysm, with related mitral valve dysfunction. The operative approach to this complex pathophysiologic process is presented.
View Article and Find Full Text PDFAssembly of graphene oxide reduced graphene oxide in a phospholipid monolayer at air-water interfaces.
Phys Chem Chem Phys
January 2025
Department of Physics, School of Natural Sciences, Shiv Nadar Institution of Eminence, NH91, Tehsil Dadri, G. B. Nagar, Uttar Pradesh 201314, India.
Graphene and its derivatives, such as graphene oxide (GO) and reduced graphene oxide (rGO), have propelled advancements in biosensor research owing to their unique physicochemical and electronic characteristics. To ensure their safe and effective utilization in biological environments, it is crucial to understand how these graphene-based nanomaterials (GNMs) interact with a biological milieu. The present study depicts GNM-induced structural changes in a self-assembled phospholipid monolayer formed at an air-water interface that can be considered to represent one of the leaflets of a cellular membrane.
View Article and Find Full Text PDF[Replacement of Left Atrioventricular Valve and Patch Augmentation of Right Atrioventricular Valve After Repair of Complete Atrioventricular Septal Defect:Report of a Case].
Kyobu Geka
November 2024
Department of Cardiovascular Surgery, Saitama Children's Medical Center, Saitama, Japan.
Reoperations can be challenging for patients who experience left and right atrioventricular valve failure after repair of a complete atrioventricular septal defect. Herein, we present a case of a 10-year-old boy who developed dysfunction in left and right atrioventricular valve following surgery for a complete atrioventricular septal defect. The patient underwent successful replacement of his left atrioventricular valve with a mechanical valve due to severe stenosis.
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