AI Article Synopsis
- CVB1 is currently the leading enterovirus worldwide, linked to meningitis and chronic health issues.
- The study focused on the genetic relationships of CVB1 by analyzing VP1 sequences from North African isolates alongside published data, revealing four genogroups and ten genotypes with notable geographical specificity.
- Advanced coalescent analysis indicated a consistent mutation rate for CVB1, aiding in the identification of circulating strains and highlighting its prevalence in human populations.
Article Abstract
Coxsackievirus type B1 (CVB1) has emerged globally as the predominant enterovirus serotype and is associated with epidemics of meningitis and chronic diseases. In this report, the phylogeny of CVB1 was studied based on the VP1 sequences of 11 North African isolates and 81 published sequences. All CVB1 isolates segregated into four distinct genogroups and 10 genotypes. Most of the identified genotypes of circulating CVB1 strains appear to have a strict geographical specificity. The North African strains were of a single genotype and probably evolved distinctly. Using a relaxed molecular clock model and three different population models (constant population, exponential growth and Bayesian skyline demographic models) in coalescent analysis using the BEAST program, the substitution rate in CVB1 varied between 6.95 × 10(-3) and 7.37 × 10(-3) substitutions/site/year in the VP1 region. This study permits better identification of circulating CVB1, which has become one of the most predominant enterovirus serotypes in humans.
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| http://dx.doi.org/10.1007/s00705-015-2561-5 | DOI Listing |
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