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Swab Testing to Optimize Pneumonia treatment with empiric Vancomycin (STOP-Vanc): study protocol for a randomized controlled trial.
Trials
December 2024
Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Background: Vancomycin, an antibiotic with activity against methicillin-resistant Staphylococcus aureus (MRSA), is frequently included in empiric treatment for community-acquired pneumonia (CAP) despite the fact that MRSA is rarely implicated in CAP. Conducting polymerase chain reaction (PCR) testing on nasal swabs to identify the presence of MRSA colonization has been proposed as an antimicrobial stewardship intervention to reduce the use of vancomycin. Observational studies have shown reductions in vancomycin use after implementation of MRSA colonization testing, and this approach has been adopted by CAP guidelines.
View Article and Find Full Text PDFChemistry to cognition: Therapeutic potential of (m-CF-PhSe) targeting rats' striatum dopamine proteins in amphetamine dependence.
Prog Neuropsychopharmacol Biol Psychiatry
December 2024
Laboratório de Avaliações Farmacológicas e Toxicológicas Aplicadas às Moléculas Bioativas (LaftamBio Pampa), Universidade Federal do Pampa, Itaqui, RS, Brazil. Electronic address:
Amphetamine (AMPH) abuse represents a major global public health issue, highlighting the urgent need for effective therapeutic interventions to manage addiction caused by this psychostimulant. This study aimed to assess the potential of m-trifluoromethyl-diphenyldiselenide [(m-CF-PhSe)] in preventing the addictive effects induced by AMPH through targeting dopamine metabolism proteins. (m-CF-PhSe) is of interest due to its demonstrated efficacy in mitigating opioid abuse, establishing it as a promising candidate for addiction treatment research.
View Article and Find Full Text PDFImpact of Coronavirus Disease 2019 Emergency Declarations on Surgeries for Deep Neck Infection Incidence in Japan.
J Infect Chemother
December 2024
Department of Otolaryngology-Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Introduction: Deep neck infections are lethal diseases; however, factors related to their prevention remain unclear. The national emergency declaration in April 2020, in response to COVID-19, spurred widespread adoption of nonpharmaceutical interventions (NPIs) such as hand washing, mask wearing, and social distancing.
Methods: This retrospective cohort study examines the impact of these interventions on the incidence of deep neck infections in Japan through interrupted time series analysis using National Database of Health Insurance Claims and Specific Health Checkups of Japan Open Data.
Guidance reconciliation and practice question prioritization for a World Health Organization's Ebola and Marburg Disease guideline.
J Clin Epidemiol
December 2024
Department of Internal Medicine, American University of Beirut, Beirut, Lebanon; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Objective: To describe the processes of reconciling overlapping guidance and prioritizing practice questions for a World Health Organization (WHO) guideline on Infection Prevention and Control (IPC) for Ebola and Marburg disease.
Methods: This work involved the reconciliation of guidance, the generation of potential practice questions and the prioritization of those questions. Contributors included the WHO secretariat, the WHO steering group, the guideline methodologists, and the guideline development group (GDG).
Microelectricity enhances aerobic granular sludge granulation and sulfamethazine degradation: Performance, mechanism, antibiotic resistance genes and microbial community.
J Environ Manage
December 2024
College of Petrochemical Engineering, Lanzhou University of Technology, Lanzhou 730050, PR China.
With the widespread use of typical antibiotics such as sulfamethazine (SMT), it leads to their accumulation in the environment, increasing the risk of the spread of antibiotic resistance genes (ARGs). Aerobic granular sludge (AGS) has shown great potential in treating antibiotic wastewater. However, the long cultivation period of AGS, the easy disintegration of particles and the poor stability of degradation efficiency for highly concentrated antibiotic wastewater are still urgent problems that need to be solved, and it is important to explore the migration and changes of ARGs and microbial diversity in AGS systems.
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