A one-pot synthesis of various GABA amides has been demostrated, employing the nucleophilic addition of primary and secondary amines across the double bond of cyclopropene-3-carboxamides, followed by ring-opening of the resulting donor-acceptor cyclopropanes and subsequent in situ reduction of enamine (imine) intermediates.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749319 | PMC |
| http://dx.doi.org/10.1039/c5ob01462j | DOI Listing |
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