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Typing Arctic and Africa-2 clades of rabies virus using clade-defining single nucleotide polymorphisms.
Arch Microbiol
January 2025
Department of Biochemistry, Division of Biological Sciences, Indian Institute of Science, Bangalore, India.
Rabies is a deadly neurotropic, zoonotic disease with a mortality rate of 100% after symptoms appear. Rabies virus (RABV) is the primary cause of rabies disease in humans, and it mainly spreads via dog bites in developing countries. Over the course of RABV evolution, multiple RABV variants, called clades, have emerged.
View Article and Find Full Text PDFBioactive glass 45S5 promotes odontogenic differentiation of apical papilla cells through autophagy.
Hua Xi Kou Qiang Yi Xue Za Zhi
February 2025
Dept. of Cariology and Endodontics, Binzhou Medical University Hospital, Binzhou 256600, China.
Objectives: The mechanism of the odontogenic differentiation of apical papillary cells (APCs) stimulated by bioactive glass 45S5 is still unclear. This study aims to investigate the effect of autophagy on the odontogenic differentiation of APCs stimulated by bioactive glass 45S5.
Methods: APCs were isolated and cultured , and the cell origin was identified by flow cytometry.
Telomeres are hypersensitive to the formation of the common oxidative lesion 8-oxoguanine (8oxoG), which impacts telomere stability and function. OGG1 and MUTYH glycosylases initiate base excision repair (BER) to remove 8oxoG or prevent mutation. Here, we show OGG1 loss or inhibition, or MUTYH loss, partially rescues telomeric 8oxoG-induced premature senescence and associated proinflammatory responses, while loss of both glycosylases causes a near complete rescue in human fibroblasts.
View Article and Find Full Text PDFUsing Transcriptomic Signatures to Elucidate Individual and Mixture Effects of Inorganic Arsenic and Manganese in Human Placental Trophoblast HTR-8/SVneo Cells.
Toxicol Sci
January 2025
Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.
Prenatal exposure to the toxic metal inorganic arsenic (iAs) is associated with adverse pregnancy and fetal growth outcomes. These adverse outcomes are tied to physiological disruptions in the placenta. While iAs co-occurs in the environment with other metals such as manganese (Mn), there is a gap in the knowledge of the effects of metal-mixtures on the placenta.
View Article and Find Full Text PDFThe role of the gut microbiota and the nicotinate/nicotinamide pathway in rotenone-induced neurotoxicity.
Curr Res Toxicol
December 2024
Institute of Toxicology, College of Preventive Medicine, Army Medical University, Chongqing 400038, China.
Rotenone is a natural compound from plants. It is widely used in pesticides because of highly toxic to insects and fish. However, lots of research has reported that rotenone has neurotoxic effects in humans.
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