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Myosin Heavy Chain Myopathy and Immune-Mediated Muscular Disorders.
Vet Clin North Am Equine Pract
January 2025
Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA.
Several inflammatory myopathies have an infectious or immune-mediated basis in the horse. Myosin heavy chain myopathy is caused by a codominant missense variant in MYH1 and has 3 clinical presentations: immune-mediated myositis, calciphylaxis, and nonexertional rhabdomyolysis in Quarter Horse-related breeds. An infarctive form of purpura hemorrhagica affects numerous breeds, presenting with focal firm, painful muscle swelling, and subsequent infarction of multiple tissues.
View Article and Find Full Text PDFSodium Thiosulfate Treatment for Calciphylaxis: Is There an Optimal Duration of Therapy?
Hemodial Int
January 2025
Nephrology Division, Medical School, Universidade de São Paulo, São Paulo, Brazil.
Calciphylaxis is a rare and serious disorder characterized by vascular calcification and occlusion of the microvessels in the dermis, subcutaneous adipose tissue, visceral organs, and musculature. Studies have suggested that the major risk factors for developing calciphylaxis are chronic kidney disease and secondary hyperparathyroidism. Its diagnosis is clinical, and the treatment includes a multidisciplinary approach, although there are no clinical protocols based on randomized clinical trials.
View Article and Find Full Text PDFManaging Calciphylaxis: Insights from Real-World Cases at a Tertiary Academic Center.
Adv Skin Wound Care
January 2025
At University of Michigan Medical School, Ann Arbor, Michigan, United States, Kanika Kochhar, DPM, is Podiatry Fellow; and Brennen O'Dell, DPM, Garneisha Torrence, DPM, MHMS, and Alton Johnson, DPM, DABPM, FACPM, FASPS, CWSP, are Clinical Assistant Professors. Carey Spitler, MSN, NP-C, CWON, is Nurse Practitioner, University of Michigan Health, Michigan Medicine, Ann Arbor. Also at University of Michigan Medical School, Brian Schmidt, DPM, is Clinical Associate Professor.
Calciphylaxis is a rare and potentially fatal condition involving chronic, nonhealing wounds caused by microvascular calcification. There is currently no approved treatment for calciphylaxis, contributing to its devastating impacts on quality of life. In this case series, the authors highlight instances of potentially misdiagnosed calciphylaxis in a cohort of patients and emphasize the importance of accurate diagnosis through multidisciplinary management approaches.
View Article and Find Full Text PDFRisk Factors Associated With the Development of Calciphylaxis in Patients With Chronic Kidney Disease: A Systematic Review.
Cureus
December 2024
Internal Medicine, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA.
Calciphylaxis is a rare but potentially life-threatening disease that is not yet completely understood. It occurs mainly in patients with chronic kidney disease termed calcific uremic arteriolopathy (CUA) but also affects patients with normal renal function. Although this disease's pathogenesis is unclear, it is associated with the dysregulation of calcium and phosphate and subsequent calcification of peripheral arterioles.
View Article and Find Full Text PDFSodium Thiosulfate: An Innovative Multi-Target Repurposed Treatment Strategy for Late-Onset Alzheimer's Disease.
Pharmaceuticals (Basel)
December 2024
Department of Physiology, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Late-onset Alzheimer's disease (LOAD) is a chronic, multifactorial, and progressive neurodegenerative disease that associates with aging and is highly prevalent in our older population (≥65 years of age). This hypothesis generating this narrative review will examine the important role for the use of sodium thiosulfate (STS) as a possible multi-targeting treatment option for LOAD. Sulfur is widely available in our environment and is responsible for forming organosulfur compounds that are known to be associated with a wide range of biological activities in the brain.
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