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Local delivery of TGF-β1-mRNA decreases fibrosis in osteochondral defects.
Bioact Mater
March 2025
Department of Orthopedics and Rehabilitation, USA.
Osteoarthritis (OA) is a condition that affects the quality of life of millions of patients worldwide. Current clinical treatments, in most cases, lead to cartilage repair with deposition of fibrocartilage tissue, which is mechanically inferior and not as durable as hyaline cartilage tissue. We designed an mRNA delivery strategy to enhance the natural healing potential of autologous bone marrow aspirate concentrate (BMAC) for articular cartilage repair.
View Article and Find Full Text PDFEvaluation of Bioprinted Autologous Cartilage Grafts in an Immunocompetent Rabbit Model.
Adv Ther (Weinh)
June 2024
Department of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty Mannheim, University of Heidelberg, Germany; Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Mannheim, University of Heidelberg, Germany.
The gold standard of auricular reconstruction involves manual graft assembly from autologous costal cartilage. The intervention may require multiple surgical procedures and lead to donor-site morbidity, while the outcome is highly dependent on individual surgical skills. A tissue engineering approach provides the means to produce cartilage grafts of a defined shape from autologous chondrocytes.
View Article and Find Full Text PDFBleximenib, the novel menin-KMT2A inhibitor JNJ-75276617, impairs long-term proliferation and immune evasion in acute myeloid leukemia.
Haematologica
December 2024
Department of Hematology, University Medical Center Groningen, University of Groningen, Groningen.
Acute myeloid leukemia (AML) remains challenging to treat, which in part relates to genetic heterogeneity of the disease, to the protective tumor microenvironment driving resistance to therapy, and also to immune evasion characteristics of leukemic cells. Targeting epigenetic programs in AML provides an attractive opportunity to impair long-term proliferation and induce differentiation. The novel inhibitor JNJ- 75276617 (bleximenib) targets the menin-KMT2A interaction and provides preclinical efficacy in AML (Kwon et al1).
View Article and Find Full Text PDFEfficacy of Ultrasound-Guided Injection of Platelet-Rich Plasma in Treatment of Sports-Related Meniscal Injuries.
Indian J Radiol Imaging
January 2025
Department of Pathology, ACS Medical College and Hospital, Chennai, Tamil Nadu, India.
Meniscal injuries are a common occurrence in sports-related activities, often leading to pain, reduced joint function, and impaired athletic performance. This study aimed to evaluate the role of ultrasound-guided intra-articular platelet-rich plasma (PRP)-rich fluid injection which was obtained through serial centrifugation in the treatment of meniscal injuries resulting from sports activities. A prospective study was conducted involving 54 cases with grade I, II, and III meniscal injuries, aged 18 and 43 years.
View Article and Find Full Text PDFA comparative analysis of platelet-rich plasma alone versus combined with extracorporeal shockwave therapy in athletes with patellar tendinopathy and knee pain: a randomized controlled trial.
Knee Surg Relat Res
December 2024
Center for Shockwave Medicine and Tissue Engineering, Medical Research, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, 833, Taiwan.
Article Synopsis
- Patellar tendinopathy, or jumper's knee, is a painful condition affecting athletes, prompting a study to evaluate the effectiveness of platelet-rich plasma (PRP) treatments alone and combined with extracorporeal shockwave therapy (ESWT).
- The study involved 33 athletes randomly assigned to receive either PRP with sham treatment or PRP plus ESWT, with follow-ups over a year to assess pain reduction and functional improvements.
- Results indicated that combining PRP with ESWT led to quicker pain relief and improved outcomes without causing discomfort or injury, supporting its effectiveness for treating chronic patellar tendinopathy in athletes.
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