AI Article Synopsis
- - This study aimed to evaluate the impact of biological rhythm disruptions in drug-naïve young adults with bipolar disorder (BD), major depressive disorder (MDD), and normal controls using specific diagnostic interviews and assessments.
- - The findings revealed that individuals with BD and MDD experienced greater disruptions in their biological rhythms compared to community controls, with BD patients showing significant impairment in sleep and social functioning.
- - The researchers concluded that both BD and MDD are linked to biological rhythm disruptions, with BD exhibiting more pronounced effects even during periods of symptom remission, suggesting that monitoring biological rhythms could aid in distinguishing between these mood disorders.
Article Abstract
Aim: To assess biological rhythm disruptions among drug-naïve young adults with bipolar disorder (BD), major depressive disorder (MDD), and community controls.
Methods: This was a cross-sectional study nested in a population-based study. BD and MDD were diagnosed using the Structured Clinical Interview for DSM-IV. Biological rhythm disruptions were assessed using the Biological Rhythm Interview of Assessment in Neuropsychiatry (BRIAN).
Results: Two hundred seventeen subjects were assessed (49 BD, 74 MDD, and 94 community controls). Biological rhythm disruption was higher in subjects with BD (40.32±9.92; p<0.001) and MDD (36.23±8.71; p<0.001) than community controls (27.67±6.88). Subjects with BD had a higher BRIAN total score (p=0.028) and higher disruption in sleep/social domains (p=0.018) as compared to MDD. In addition, the BRIAN scores were higher in current MDD, euthymic BD, and BD in current episode group, as compared to community controls.
Limitation: Cross-sectional design. Absence of assessment of biomarkers of biological rhythms.
Conclusion: Bipolar disorder and major depressive disorder are associated with disruption in biological rhythm. In addition, disruption in sleep/social rhythms is higher in subjects with BD when compared to subjects with MDD. We also verified biological rhythm disruption in subjects with BD during euthymic status, but not in remitted MDD. Regulation of biological rhythm may be a means to identify patients with mood disorders and potentially differentiate MDD from BD.
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| http://dx.doi.org/10.1016/j.jad.2015.07.004 | DOI Listing |
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