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Use of psychoactive medications in topical cream: Need for regulation and vigilance!
Am J Emerg Med
January 2025
Department of Anesthesiology and Critical Care, All India Institute of Medical Sciences, Bhubaneswar, India.
The Two Sides of Placebo Analgesia: Differential Functional Connectivity Reveals Mechanisms of Placebo Analgesic Response.
J Pain Res
January 2025
Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
Background: Previous research has demonstrated that placebo induction manipulations can reduce an individual's pain through non-specific mechanisms, such as expectancy manipulations. However, despite robust research characterizing these effects, individual differences in predicting placebo analgesic responses are not well understood.
Methods: Fifty-four healthy pain-free adults over 18 (M=22.
High-Throughput Dissociation and Orthotopic Implantation of Breast Cancer Patient-Derived Xenografts.
J Vis Exp
December 2024
Division of Exercise Physiology, Department of Health Professions, West Virginia University School of Medicine; Cancer Institute, West Virginia University School of Medicine; 3Department of Microbiology, Immunology, and Cell Biology, West Virginia University School of Medicine;
Article Synopsis
- Patient-derived xenografts (PDXs) offer a valuable approach to study breast cancer (BC) by mimicking real tumor environments and systemic effects, which in vitro models cannot achieve.
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Systemic ketamine toxicity following dermal application of a compounded pain cream.
Am J Emerg Med
December 2024
Cook County Health, Chicago, IL, USA.
Ketamine is an NMDA receptor antagonist commonly used as a dissociative anesthetic and analgesic. Though it is conventionally administered via the intravenous, intramuscular, or intranasal route, use as a compounded analgesic cream is becoming increasingly common. This is a case report of a 61-year-old man who was detained by the police for erratic driving.
View Article and Find Full Text PDFEfficacy of 4% tetracaine gel and lidocaine-prilocaine cream in reducing local anesthetic injection pain in upper eyelid blepharoplasty: a randomized, single-blinded, controlled trial.
BMC Ophthalmol
December 2024
Department of Ophthalmology, The Second Hospital of Dalian Medical University, Dalian, Liaoning Province, China.
Background: The injection of local anesthetics, an extremely painful procedure, leads to a reduction of patients' acceptance.
Objective: To investigate the efficacy and adverse reactions of 4% tetracaine gel (TG) and lidocaine-prilocaine cream (LPC) on reducing the local anesthetic injection pain for upper eyelid blepharoplasty.
Methods: Sixty participants were equally divided into three groups.
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