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Management of serum calcium reductions among patients on hemodialysis following cinacalcet initiation. | LitMetric

AI Article Synopsis

  • Cinacalcet is used to treat secondary hyperparathyroidism in hemodialysis patients by lowering serum calcium levels through decreased parathyroid hormone secretion.
  • A study involving 13,723 patients showed that nearly 47% experienced a reduction in calcium levels to below 8.4 mg/dL, with most achieving levels between 8.0-8.3 mg/dL.
  • The majority of patients recovered their calcium levels back to 8.4 mg/dL or higher within 90 days, regardless of whether they received additional treatment or discontinued cinacalcet.

Article Abstract

Purpose: Cinacalcet is indicated for treatment of secondary hyperparathyroidism in patients receiving hemodialysis. Cinacalcet reduces serum calcium concentrations by decreasing parathyroid hormone secretion, but the frequency and degree of calcium reduction following cinacalcet initiation, subsequent physician response, and ultimate calcium recovery in clinical practice are not well described.

Methods: Patients receiving hemodialysis at a large dialysis organization who enrolled in the organization's prescription benefits service and initiated cinacalcet at serum calcium ≥8.4 mg/dL were studied (N = 13 723). Patients were categorized by whether they experienced a reduction in calcium to <8.4 mg/dL and to what level (<7.5, 7.5-7.9, and 8.0-8.3 mg/dL). Baseline characteristics, frequency of subsequent intervention, and calcium recovery were compared.

Results: Of those who experienced a reduction in calcium to <8.4 mg/dL (n = 6437 [46.9%]), 6.6% had calcium <7.5 mg/dL and 24.5% had calcium 7.5-7.9 mg/dL, while the majority (68.9%) had a level of 8-8.3 mg/dL. Higher baseline parathyroid hormone and alkaline phosphatase were associated with lower resultant calcium. Among patients with calcium reductions, 45.6-63.5% received one or more directed clinical therapeutic responses, including 15.6-28.4% for whom cinacalcet was discontinued; the majority of patients recovered to calcium ≥8.4 mg/dL within 90 days of first detection. Only modest differences in recovery were noted between patients who did and did not receive any therapeutic response and patients who did and did not discontinue cinacalcet.

Conclusion: Serum calcium reductions following cinacalcet initiation were common; declines <7.5 mg/dL were infrequent. Calcium recovery occurred in the majority of patients, with or without therapeutic intervention.

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Source
http://dx.doi.org/10.1002/pds.3845DOI Listing

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