Bipolar disorder is a severe affective disorder which can present in adolescence, or sometimes earlier, and often requires a pharmacotherapeutic approach. The phenomenology of bipolar disorder in children and adolescents appears to differ from that of adult patients, prompting the need for specific pharmacotherapy guidelines for long-term management in this patient population. Current treatment guidelines were mainly developed based on evidence from studies in adult patients, highlighting the requirement for further research into the pharmacotherapy of children and adolescents with bipolar disorder. This review compares and critically analyzes the available guidelines, discussing the recommended medication classes, their mechanisms of action, side effect profiles and evidence base.
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http://dx.doi.org/10.3390/jcm3010135 | DOI Listing |
Nat Commun
December 2024
Department of Neuroscience, Baylor College of Medicine, Houston, TX, 77030, USA.
The bipolar disorder (BD) risk gene ANK3 encodes the scaffolding protein AnkyrinG (AnkG). In neurons, AnkG regulates polarity and ion channel clustering at axon initial segments and nodes of Ranvier. Disruption of neuronal AnkG causes BD-like phenotypes in mice.
View Article and Find Full Text PDFTransl Psychiatry
December 2024
School of Computer Science and Technology (School of Data Science), Taiyuan University of Technology, Taiyuan, 030024, China.
Bipolar disorder (BD) is a neuropsychiatric disorder characterized by severe disturbance and fluctuation in mood. Dynamic functional connectivity (dFC) has the potential to more accurately capture the evolving processes of emotion and cognition in BD. Nevertheless, prior investigations of dFC typically centered on larger time scales, limiting the sensitivity to transient changes.
View Article and Find Full Text PDFCureus
November 2024
Department of Public Health and Environmental Medicine, The Jikei University School of Medicine, Tokyo, JPN.
Little is known about the effectiveness of pharmacotherapy in dissociative identity disorder (DID). Zinc is essential for proper brain function. Its deficiency can lead to mental health symptoms, possibly contributing to dissociation.
View Article and Find Full Text PDFFront Public Health
December 2024
Department of Government and Public Policy, Faculty of Contemporary Studies, National Defence University, Islamabad, Pakistan.
Introduction: Globally, one in five individuals faces unemployment, which substantially increases their risk of developing mental disorders. Understanding the relationship between unemployment and specific mental health outcomes is crucial for formulating effective policy interventions.
Methods: This study examines the relationship between unemployment and mental disorders across 201 countries from 1970 to 2020.
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