Mouse Models of Uncomplicated and Fatal Malaria.

Mouse models have demonstrated utility in delineating the mechanisms underlying many aspects of malaria immunology and physiology. The most common mouse models of malaria employ the rodent-specific parasite species , , and , which elicit distinct pathologies and immune responses and are used to model different manifestations of human disease. culture methods are not well developed for rodent parasites, which thus require maintenance. Moreover, physiologically relevant immunological processes are best studied . Here, we detail the processes of infecting mice with , maintaining the parasite , and monitoring parasite levels and health parameters throughout infection.