A series of novel 2,4-diaminopyrimidine compounds bearing bicyclic aminobenzazepine were synthesized and evaluated for their anti-ALK activities. The activities of these compounds were confirmed in both enzyme- and cell-based ALK assays. Amongst compounds synthesized, KRCA-0445 showed very promising results in pharmacokinetic study and in vivo efficacy study with H3122 xenograft mouse model.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bmcl.2015.07.004 | DOI Listing |
Publication Analysis
Top Keywords
bearing bicyclic
8
synthesis evaluation
4
evaluation novel
4
novel 24-diaminopyrimidines
4
24-diaminopyrimidines bearing
4
bicyclic aminobenzazepines
4
aminobenzazepines anaplastic
4
anaplastic lymphoma
4
lymphoma kinase
4
kinase alk
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!