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Unlabelled: The past decade has seen remarkable progress in identifying genes that, when impacted by deleterious coding variation, confer high risk for autism spectrum disorder (ASD), intellectual disability, and other developmental disorders. However, most underlying gene discovery efforts have focused on individuals of European ancestry, limiting insights into genetic risks across diverse populations. To help address this, the Genomics of Autism in Latin American Ancestries Consortium (GALA) was formed, presenting here the largest sequencing study of ASD in Latin American individuals (n>15,000).
View Article and Find Full Text PDFPrenatal exposure to environmental bisphenols over time and their association with childhood asthma, allergic rhinitis and atopic dermatitis in the ECHO consortium.
Environ Pollut
November 2024
Division of Research Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA, USA. Electronic address:
Concerns persist about the potential impact of prenatal exposure to bisphenols (BP) and their replacement analogues on childhood asthma and allergies. Previous studies on single and small cohorts had limited statistical power, few investigated analogues BPF and BPS, and even fewer examined atopic outcomes. Our objective was to assess whether prenatal exposures to individual environmental bisphenols (BPA, BPF, BPS) influence risk of childhood asthma, allergic rhinitis, and atopic dermatitis.
View Article and Find Full Text PDF[This corrects the article DOI: 10.1183/23120541.00838-2023.
View Article and Find Full Text PDFSeasonal mood variation in youth and young adults with bipolar spectrum disorder: A longitudinal prospective analysis.
J Affect Disord
February 2025
Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Article Synopsis
- - The study aimed to find out if mood episodes (depression and mania) in young people with Bipolar Spectrum Disorder vary by latitude and seasons.
- - Researchers evaluated mood in 413 participants over nearly 92 months, finding that depressive episodes were more frequent in winter, while manic episodes were more common in summer.
- - The findings suggest the need for strategies to manage the seasonal impacts on mood for individuals with Bipolar Disorder, especially recognizing the differences across various locations.
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