AI Article Synopsis
- The study aimed to compare brain volumes in infants with congenital heart disease (CHD) to healthy counterparts and to assess brain growth.
- Researchers conducted a prospective cohort study, using MRI to measure brain volumes in infants undergoing open-heart surgery for complex CHD, excluding those with visible brain lesions.
- Findings revealed that infants with CHD had significantly smaller total and regional brain volumes before surgery, indicating that the reduced brain growth likely originates in the womb rather than as a result of the heart condition.
Article Abstract
Objectives: To determine neonatal global and regional brain volumes in infants with congenital heart disease (CHD) in comparison with healthy controls and to determine brain growth.
Study Design: Prospective cohort study in infants undergoing open-heart surgery for complex CHD. Global and regional volumetric measurements on preoperative cerebral magnetic resonance imaging were manually segmented in children without overt brain lesions.
Results: Preoperative brain volumetry of 19 patients demonstrates reduction in total and regional brain volumes, without any specific regional predilection compared with 19 healthy control infants (total brain volume reduction: 21%, regional brain volume reduction 8%-28%, all P < .001).
Conclusions: Infants with CHD undergoing bypass surgery have smaller brain volumes prior to surgery without a specific regional predilection. This suggests a fetal origin of reduced brain growth.
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Source |
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| http://dx.doi.org/10.1016/j.jpeds.2015.07.006 | DOI Listing |
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