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Association Between Cigarette Smoking and Subclinical Markers of Cardiovascular Harm.
J Am Coll Cardiol
March 2025
Ciccarone Center for Prevention of Cardiovascular Disease, Johns Hopkins Medicine, Baltimore, Maryland, USA; American Heart Association Tobacco Regulation and Addiction Center, Dallas, Texas, USA. Electronic address:
Background: Cigarette smoking is a strong risk factor for cardiovascular harm.
Objectives: The study sought to explore the detailed relationships between smoking intensity, pack-years, and time since cessation with inflammation, thrombosis, and subclinical atherosclerosis markers of cardiovascular harm.
Methods: We included 182,364 participants (mean age 58.
The Role of Mitochondrial DNA Copy Number in Venous Thromboembolism: Insights from a 2-Sample Mendelian Randomization Study.
Ann Vasc Surg
April 2025
Department of Cardiology, Dongying People's Hospital (Dongying Hospital of Shandong Provincial Hospital Group), Dongying, China. Electronic address:
Background: Venous thromboembolism (VTE), including pulmonary embolism (PE) and deep vein thrombosis (DVT), is the third most common cardiovascular disease. A low amount of mitochondrial DNA copy number (mtDNA-CN) reflects mitochondrial dysfunctions and has been associations with arterial cardiovascular diseases. However, the role of mtDNA-CN in venous cardiovascular disease was unclear.
View Article and Find Full Text PDFAcute Pulmonary Embolism: The Clinical Value of Early Follow-Up Computed Tomography Imaging in Thrombus Regression and Rare Differential Diagnoses of Pulmonary Intimal Sarcoma.
J Atheroscler Thromb
March 2025
Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine.
Transfusion of Fresh Frozen Plasma and Platelets in Critically Ill Adults An American College of Chest Physicians Clinical Practice Guideline.
Chest
March 2025
Division of Pulmonary and Critical Care Medicine, Henry Ford Hospital, Detroit, MI.
Background: Platelets and fresh frozen plasma (FFP) are frequently administered to critically ill patients. Considering the variability in indications and thresholds guiding these transfusions, a comprehensive review of current evidence was conducted to provide guidance to critical care practitioners. This CHEST guideline examined the literature on platelet transfusions in critically ill patients with thrombocytopenia, with and without active bleeding, as well as data on prophylactic platelet and FFP transfusions for common procedures in the critical care setting.
View Article and Find Full Text PDFCan apelins guide the diagnosis of coronary artery disease in COPD patients?
Heart Lung
March 2025
Depertment of Pulmonary Diseases, Ataturk University School of Medicine, Yakutiye, Erzurum, Turkey.
Background: Apelins are adipokines known for their anti-inflammatory, vasodilator, and antiatherosclerotic effects. They are involved in the pathogenesis of chronic diseases like chronic obstructive pulmonary disease (COPD) and coronary artery disease (CAD).
Objectives: This study aims to investigate apelin as a potential biomarker for early diagnosis and management of CAD in COPD patients.
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