The essential details of cellular interactions at synaptic level in the brain are still largely unknown. In this issue, Kasthuri et al. report new experimental and computational technologies for large-scale electron microscopy data collection and analysis, and through saturated reconstruction uncover synaptic connectional specificity that cannot be predicted by simple axonal-dendritic proximity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.cell.2015.07.031 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Correlated spin-wave generation and domain-wall oscillation in a topologically textured magnetic film.
Nat Mater
January 2025
Condensed Matter Physics and Materials Science Division, Brookhaven National Laboratory, Upton, NY, USA.
Spin waves, or magnons, are essential for next-generation energy-efficient spintronics and magnonics. Yet, visualizing spin-wave dynamics at nanoscale and microwave frequencies remains a formidable challenge due to the lack of spin-sensitive, time-resolved microscopy. Here we report a breakthrough in imaging dipole-exchange spin waves in a ferromagnetic film owing to the development of laser-free ultrafast Lorentz electron microscopy, which is equipped with a microwave-mediated electron pulser for high spatiotemporal resolution.
View Article and Find Full Text PDFSustainability metrics targeted optimization and electric discharge process modelling by neural networks.
Sci Rep
January 2025
Center for Automation and Robotics, CSIC-Universidad Politécnica de Madrid, Arganda del Rey, Madrid, 28500, Spain.
Aluminium and its alloys, especially Al6061, have gathered significant interest among researchers due to its less density, great durability, and high strength. Due to their lightweight properties, the precise machining of these alloys can become expensive through conventional machining operations for intricate products. Therefore, non-traditional machining such as electric discharge machining (EDM) can potentially be opted for the cutting of Al6061.
View Article and Find Full Text PDFThe Diagnostic Assessment of Inherited Platelet Function Defects.
Hamostaseologie
January 2025
Center for Clinical Transfusion Medicine Tuebingen, Tuebingen, Germany.
In this article, our goal is to offer an introduction and overview of the diagnostic approach to inherited platelet function defects (iPFDs) for clinicians and laboratory personnel who are beginning to engage in the field. We describe the most commonly used laboratory methods and propose a diagnostic four-step approach, wherein each stage requires a higher level of expertise and more specialized methods. It should be noted that our proposed approach differs from the ISTH Guidance on this topic in some points.
View Article and Find Full Text PDFAsymmetries in the Architecture of ON and OFF Arbors in ON-OFF Direction-Selective Ganglion Cells.
J Comp Neurol
January 2025
Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai, Tamil Nadu, India.
Direction selectivity is a fundamental feature in the visual system. In the retina, direction selectivity is independently computed by ON and OFF circuits. However, the advantages of extracting directional information from these two independent circuits are unclear.
View Article and Find Full Text PDFGreen synthesis of silica-coated gold nanoparticles employing femtosecond laser, solid targets, and water.
Discov Nano
January 2025
Nuclear and Energy Research Institute, IPEN, CNEN/SP, Av. Prof. Lineu Prestes, 2242, São Paulo, SP, CEP05508-000, Brazil.
Gold nanoparticles are widely used in biomedical applications due to their unique properties. However, traditional synthesis methods generate contaminants that cause cytotoxicity and compromise the biocompatibility of the nanomaterials. Therefore, green synthesis methods are essential to produce pure and biocompatible nanoparticles, ensuring their effectiveness in biomedical applications.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!