AI Article Synopsis
- Bronchiectasis is often found in rheumatoid arthritis (RA) patients, but its prevalence and predictors are not well understood; this study aims to investigate these factors in RA patients at a Saudi Arabian hospital.
- Researchers conducted an observational study on 100 asymptomatic RA patients, using demographic, clinical, and laboratory data to assess bronchiectasis prevalence through imaging and disease activity measurement.
- The study found that 35% of RA patients had bronchiectasis, with significant associations identified with factors like age, disease duration, and male gender, highlighting the need for risk assessment in RA management.
Article Abstract
Introduction And Objectives: Bronchiectasis is a pulmonary manifestation that often occurs in individuals with rheumatoid arthritis (RA). Nevertheless, the prevalence of bronchiectasis in RA patients and predictors of its development/progression remain ill-defined. Our objective was to investigate the prevalence of bronchiectasis in a group of RA patients and examine possible clinical or biochemical risk factors that might contribute to its development.
Methods: This was an observational study analyzing 100 RA patients with no pulmonary symptoms selected from King Abdulaziz University Hospital in the Western region of Saudi Arabia from October 2013 to 2014. Demographic, clinical and laboratory information were collected for all patients. Diagnosis was based on the 2010 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification system, and disease activity was assessed using the 28-Joint Disease Activity Score Index with C-reactive protein; high-resolution computed tomography chest scans were performed. The prevalence of bronchiectasis was recorded and its association with different risk factors was examined using standard statistical methods.
Results: All 100 patients fulfilled the ACR and EULAR classification criteria for RA diagnosis. Their mean age was 51.05 ± 13.5 years, disease duration was 6.19 ± 6.4 years and disease activity index was 4 ± 1.3 (moderate activity). A total of 35 (35%) patients developed bronchiectasis. Notably, we observed significant positive associations of bronchiectasis with age, disease duration and male gender (P < 0.001, P = 0.006, P = 0.028, respectively).
Conclusions: Asymptomatic bronchiectasis represents a common complication in moderately active RA patients within the Western Region of Saudi Arabia. Furthermore, several predictors of bronchiectasis development were identified, which can contribute to effective risk stratification in RA patients. Further prospective studies are needed to detect the prognosis of asymptomatic bronchiectasis in RA patients.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518347 | PMC |
| http://dx.doi.org/10.4103/1817-1737.160836 | DOI Listing |
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