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Unraveling propylene glycol-induced lipolysis of the biosynthesis pathway in ultra-high temperature milk using high resolution mass spectrometry untargeted lipidomics and proteomics.
Food Res Int
February 2023
School of Food and Biological Engineering, Shaanxi University of Science & Technology, Xi'an 710021, China.
In July 2022, the food safety accident that excessive propylene glycol was detected in milk processing factory raised widespread concerns about quality and nutrition of milk with illegal additive. To the best of our knowledge, the influences of propylene glycol to lipids in milk had not been systematically explored. Therefore, spatiotemporal distributions of lipids related to propylene glycol reaction and changes of sensory quality were investigated by food exogenous.
View Article and Find Full Text PDFInhibitory effect of mesna and 5-fluorouracil on propylene glycol-induced cholesteatoma in rats.
Acta Otorhinolaryngol Ital
October 2021
Istanbul Medeniyet University, Faculty of Medicine, Goztepe Training and Research Hospital, Department of Otorhinolaryngology, Istanbul, Turkey.
Objective: The aim of this study was to investigate the inhibitory effect of different doses of sodium-2-mercaptoethanesulphonate (MESNA) and 5-fluorouracil on cholesteatoma formation.
Methods: Fifty-six Wistar albino male rats were divided into seven groups with eight rats in each. On the first, eighth and fifteenth days, 0.
Etomidate and propylene glycol activate nociceptive TRP ion channels.
Mol Pain
February 2019
1 Institute of Physiology and Pathophysiology, Friedrich-Alexander-University Erlangen-Nuernberg, Erlangen, Germany.
Background: Etomidate is a preferred drug for the induction of general anesthesia in cardiovascular risk patients. As with propofol and other perioperatively used anesthetics, the application of aqueous etomidate formulations causes an intensive burning pain upon injection. Such algogenic properties of etomidate have been attributed to the solubilizer propylene glycol which represents 35% of the solution administered clinically.
View Article and Find Full Text PDFPentobarbital-induced lactic acidosis following status epilepticus barbiturate coma.
BMJ Case Rep
February 2018
Department of Medicine, University of Arizona, Tucson, Arizona, USA.
We present a rare case of pentobarbital infusion causing propylene glycol-induced lactic acidosis, during refractory status epilepticus treatment in a 66-year-old man without seizure history.
View Article and Find Full Text PDFSingle dose intratympanic mesna application inhibits propylene glycol induced cholesteatoma formation.
J Laryngol Otol
March 2017
Department of Otorhinolaryngology,Faculty of Medicine, University of Mersin,Turkey.
Objective: Mesna (i.e. sodium 2-mercaptoethanesulfonate; C2H5NaO3S2) has been used in otological surgery such as cholesteatoma dissection and tympanic membrane lateralisation in atelectatic ears.
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