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AAVR Expression is Essential for AAV Vector Transduction in Sensory Hair Cells.
Adv Sci (Weinh)
January 2025
Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510120, China.
Adeno-associated virus (AAV) vectors are a leading platform for gene therapy. Recently, AAV-mediated gene therapy in the inner ear has progressed from laboratory use to clinical trials, but the lower transduction rates in outer hair cells (OHCs) in the organ of Corti and in vestibular hair cells in adult mice still pose a challenge. OHCs are particularly vulnerable to inner ear insults.
View Article and Find Full Text PDFEffects of dimethylarsenate coprecipitation with ferrihydrite on Fe(II)-induced mineral transformation and the release of dimethylarsenate.
Environ Pollut
December 2024
Key Laboratory of Arable Land Conservation (Middle and Lower Reaches of Yangtse River), Ministry of Agriculture and Rural Affairs, College of Resources and Environment, Huazhong Agricultural University, Wuhan, 430070, China; Hubei Key Laboratory of Soil Environment and Pollution Remediation, College of Resources and Environment, Wuhan, 430070, China. Electronic address:
Organoarsenicals are toxic pollutants of global concern, and their environmental geochemical behavior might be greatly controlled by iron (Fe) (hydr)oxides through coprecipitation, which is rarely investigated. Here, the effects of the incorporation of dimethylarsenate (DMAs(V)), a typical organoarsenical, into the ferrihydrite (Fh) structure on the mineral physicochemical properties and Fe(II)-induced phase transformation of DMAs(V)-Fh coprecipitates with As/Fe molar ratios up to 0.0876 ± 0.
View Article and Find Full Text PDFReliability of ameloglyphics in forensic identification: a systematic review.
Int J Legal Med
December 2024
Department of Oral and Maxillofacial Pathology and Microbiology, KLE Vishwanath Katti Institute of Dental Sciences, KLE Academy of Higher Education and Research, Belagavi, 590010, Karnataka, India.
Background: Teeth are considered as hard tissue analogue to fingerprints, being unique to an individual. The enamel which forms the outer layer of the tooth is formed through a highly dynamic process in which ameloblasts lay down enamel rods in an undulating and intertwining path, which is reflected as a series of enamel rod pattern. The study of these patterns is termed as "Ameloglyphics".
View Article and Find Full Text PDFBarriers and facilitators to the implementation of guidelines for venous thromboembolism prevention and management: A mixed-methods systematic review.
Int J Nurs Stud Adv
June 2025
Nursing Department, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Background: Evidence-based venous thromboembolism prevention and management is a priority for global health services. Low adoption of venous thromboembolism guidelines can result in compromised patient outcomes. Understanding clinicians' and patients' perceptions of barriers to and facilitators for guideline implementation and mapping identified barriers and facilitators to the Consolidated Framework for Implementation Research may inform theoretical interventions to improve guideline adoption rates.
View Article and Find Full Text PDFCargo exchange between human and bacterial extracellular vesicles in gestational tissues: a new paradigm in communication and immune development.
Extracell Vesicles Circ Nucl Acids
June 2024
Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Article Synopsis
- Host-bacteria and bacteria-bacteria interactions can occur through extracellular vesicles (EVs) secreted by both human and bacterial cells, allowing for immune responses without direct bacterial colonization.
- In the feto-maternal interface, BEVs have been found in the placenta and amniotic cavity, potentially aiding in fetal immune system development while avoiding harmful immune reactions during pregnancy.
- The study of these interactions, including the uptake of BEVs by human cells and their effects on feto-maternal health, especially concerning complications like preeclampsia and preterm birth, is not yet fully understood.
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