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Old Problem in a New Guise: Retinal Pigment Epithelium Tear after Intravitreal Faricimab (Vabysmo) Injection.
Case Rep Ophthalmol
May 2023
Department of Ophthalmology, University of Münster, Münster, Germany.
This case report describes a 78-year-old patient who developed a tear of the retinal pigment epithelium (RPE) during faricimab (Vabysmo) therapy. After three consecutive intravitreal aflibercept (Eylea) injections with persistent disease activity, therapy was switched to faricimab. The patient experienced a tear in the RPE 4 weeks postinjection.
View Article and Find Full Text PDFOld but Gold: Tracking the New Guise of Histone Deacetylase 6 (HDAC6) Enzyme as a Biomarker and Therapeutic Target in Rare Diseases.
J Med Chem
January 2020
Department of Biotechnology, Chemistry and Pharmacy, Department of Excellence 2018-2022 , University of Siena, via Aldo Moro 2 , 53100 , Siena , Italy.
Epigenetic regulation orchestrates many cellular processes and greatly influences key disease mechanisms. Histone deacetylase (HDAC) enzymes play a crucial role either as biomarkers or therapeutic targets owing to their involvement in specific pathophysiological pathways. Beyond their well-characterized role as histone modifiers, HDACs also interact with several nonhistone substrates and their increased expression has been highlighted in specific diseases.
View Article and Find Full Text PDFUnder the guise of retinitis.
JAMA Ophthalmol
October 2015
Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts.
Random-dot stereopsis in microstrabismic children: stimulus size matters.
Optom Vis Sci
February 2015
*OD, MSc †PhD Département de sciences biomédicales (MP), École d'optométrie, (MP, DdG), Département ophtalmologie (DS-A), Département de psychologie (DS-A), Université du Québec à Montréal, Québec, Canada; and Centre de recherche, CHU Sainte-Justine, Montréal, Québec, Canada (MP, DS-A).
Purpose: Although children with microstrabismus demonstrate stereoscopic abilities when assessed with clinical tests containing visible contours (local stereopsis), severe stereoscopic impairments are reported when using random-dot stereogram (RDS). This differential performance may be associated with the decreasing interocular correlation resulting from the central suppression present in the deviated eye, affecting global stereopsis to a greater extent.
Methods: To test this hypothesis, stereoscopic performance on tasks using contour/local (experiment 1), RDS depth (experiment 2), and RDS shape discrimination (experiment 3) was obtained in nine microstrabismic children and compared with that of control participants.
Age-related macular degeneration: beyond anti-angiogenesis.
Mol Vis
January 2014
The Vision Clinic, Circular Road, Kilkenny, Ireland ; Institute of Ageing and Chronic Disease, Faculty of Health & Life Sciences, University of Liverpool, UK.
Recently, anti-vascular endothelial growth factor therapies for neovascular age-related macular degeneration have been developed. These agents, originally developed for their anti-angiogenic mechanism of action, probably also work through an anti-permeability effect in preventing or reducing the amount of leakage from submacular neovascular tissue. Other treatment modalities include laser photocoagulation, photodynamic therapy with verteporfin, and submacular surgery.
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