The purpose of the present study is to confirm the protective effect of berberine (BBR) on gastrointestinal injury caused by acute heavy alcohol exposure, an effect that has not been reported previously. Our research details how BBR protects against gastrointestinal injuries from acute alcohol exposure using both in vivo and in vitro experiments. Acute high alcohol concentrations lead to obvious damage to the gastrointestinal mucosa, resulting in necrosis of the intestinal mucosa. Oral administration of BBR was able to significantly reduce this alcohol-induced damage, inhibit increases of alcohol-induced TNFα and IL-1β expression in gastrointestinal mucosa as well as their upstream signals TLR2 and TLR4, and regulate cytokines that modulate tight junctions. Alcohol consumption is a popular human social behavior worldwide, and the present study reports a comprehensive mechanism by which BBR protects against gastrointestinal injuries from alcohol stress, providing people with a novel application of BBR.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520689 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0134044 | PLOS |
Publication Analysis
Top Keywords
Similar Publications
Gut IgA-antibody secreting cells segregate into four Blimp1+ subsets based on differential expression of IgA and Ki-67 and are retained following prolonged αCD20 B cell depletion in mice.
J Immunol
March 2025
Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI, United States.
B cell depletion is an efficacious therapy for multiple sclerosis, but its long-term safety profile in the gastrointestinal tract has not been specifically studied. This is of importance because the gut is the largest reservoir of IgA in the body, which maintains gut homeostasis in part by regulating the composition of the gut microbiota. This was addressed by development of a prolonged B cell depletion model using human CD20 transgenic mice and B cell depletion with the anti-human CD20 antibodies rituximab, a humanized mouse monoclonal, and 2H7, the mouse precursor to ocrelizumab.
View Article and Find Full Text PDFMalignant Melanoma of External Auditory Canal: A Rare Case Report.
Indian J Otolaryngol Head Neck Surg
January 2025
Department of Head and Neck Oncology, Mahatma Gandhi Cancer Hospital, Miraj, Maharashtra India.
Malignant melanoma (MM) is predominantly seen in the skin, but it can also be seen in the eyes, ear, gastrointestinal tract, genital tract and mucous membrane of the oral cavity. MM of the ear accounts 1-4% of all cutaneous melanomas. In ear, pinna is the most common site.
View Article and Find Full Text PDFMicrobiota and metabolite-based prediction tool for colonic polyposis with and without a known genetic driver.
Gut Microbes
December 2025
Division of Digestive & Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Despite extensive investigations into the microbiome and metabolome changes associated with colon polyps and colorectal cancer (CRC), the microbiome and metabolome profiles of individuals with colonic polyposis, including those with (Gene-pos) and without (Gene-neg) a known genetic driver, remain comparatively unexplored. Using colon biopsies, polyps, and stool from patients with Gene-pos adenomatous polyposis ( = 9), Gene-neg adenomatous polyposis ( = 18), and serrated polyposis syndrome (SPS, = 11), we demonstrated through 16S rRNA sequencing that the mucosa-associated microbiota in individuals with colonic polyposis is representative of the microbiota associated with small polyps, and that both Gene-pos and SPS cohorts exhibit differential microbiota populations relative to Gene-neg polyposis cohorts. Furthermore, we used these differential microbiota taxa to perform linear discriminant analysis to differentiate Gene-neg subjects from Gene-pos and from SPS subjects with an accuracy of 89% and 93% respectively.
View Article and Find Full Text PDFApigenin improves chronic gastric ulcer in rats: The implication of COX-1/2 and 5-LOX signaling pathways.
Tissue Cell
March 2025
Department of Human Anatomy and Embryology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt; Department of Anatomy, College of Medicine and Health Sciences, Arabian Gulf University, Manama, Bahrain. Electronic address:
Peptic ulcer is a prevalent gastrointestinal illness. The aim is to investigate the possible implication of cyclooxygenase (COX)-1/2 and 5-lipoxygenase (5-LOX) signaling pathways in apigenin therapeutic effect on acetic acid-induced chronic gastric ulcer maintained with indomethacin. Rats were divided into 5 groups (n = 10): control, ulcer, omeprazole+ulcer, apigenin+ulcer, and apigenin only groups.
View Article and Find Full Text PDFUPPER DIGESTIVE ENDOSCOPY IN CAPTIVE COATIS (, LINNAEUS, 1766).
J Zoo Wildl Med
March 2025
Department of Veterinary Surgery and Animal Reproduction, School of Veterinary Medicine and Animal Science, São Paulo State University, Botucatu, 18618-681, São Paulo, Brazil.
This study aimed to perform upper digestive endoscopy in clinically healthy coatis (), based on descriptions in domestic dogs and cats. In addition, research was carried out for r in stomach samples. Five adult male coatis, weighing between 2.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!