AI Article Synopsis
- FGF21 is an important factor that regulates glucose and lipid metabolism, and its levels are elevated in individuals with heart diseases.
- The study involved THP1 macrophages being induced into foam cells to observe the effects of FGF21 on cholesterol accumulation and cell death.
- Results showed that FGF21 reduced cholesterol levels and prevented apoptosis in foam cells by inhibiting the expression of CHOP.
Article Abstract
Background: FGF21,as a member of the fibroblast growth factor superfamily, is an important endogenous regulator to systemic glucose and lipid metabolism. Elevated serum FGF21 levels have been reported in subjects with coronary heart disease and carotid artery plaques. The formation and apoptosis of foam cell, induced by ox-LDL and oxysterols, are key steps in the development of atherosclerosis.
Methods: In this study, THP1 derived macrophages were induced into foam cells by ox-LDL or sterols. The formation and apoptosis of foam cells treated with or without FGF21 were analyzed.
Results: We demonstrated that the accumulation of cholesterol was decreased after FGF21 treatment in THP1 macrophage derived foam cells. Consistently, the apoptosis of macrophage was alleviated dramatically with FGF21 treatment. ERK1/2 knockdown didn't abrogate the effect of FGF21 on THP1 macrophage derived foam cells. However, FGF21 suppressed the induced expression of CHOP and DR5 in THP1 macrophage derived foam cells.
Conclusion: FGF21 protects against the formation and apoptosis of THP1 macrophages derived foam cells through suppressing the expression of CHOP.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518604 | PMC |
| http://dx.doi.org/10.1186/s12872-015-0077-2 | DOI Listing |
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