AI Article Synopsis

  • The study aimed to assess lymph node status in women with endometrial cancer referred to a Brazilian oncology center, focusing on clinicopathological factors that could suggest the exclusion of lymphadenectomy.
  • Researchers analyzed data from 310 women with different types of endometrial cancer, evaluating factors like tumor size, grade, invasion depth, and lymphovascular space invasion to identify correlations with lymph node metastasis.
  • Findings indicated that tumor size, myometrial invasion, tumor grade, and lymphovascular space invasion were significantly associated with lymph node involvement, while histological type was not, leading to recommendations for timely hysterectomy and a reevaluation of lymph node dissection needs.

Article Abstract

Objective: The aim of this study was to determine the lymph node status in a large cohort of women with endometrial cancer from the public health system who were referred to an oncology reference center in Brazil to identify candidates for the omission of lymphadenectomy based on clinicopathological parameters.

Methods: We retrospectively analyzed a cohort of 310 women with endometrial cancer (255 endometrioid, 40 serous, and 15 clear cell tumors) treated between 2009 and 2014. We evaluated the histological type, grade (low vs. high), tumor size (cm), depth of myometrial invasion (≤50%, >50%) and lymphovascular space invasion to determine which factors were correlated with the presence of lymph node metastasis.

Results: The factors related to lymph node involvement were tumor size (p=0.03), myometrial invasion (p<0.01), tumor grade (p<0.01), and lymphovascular space invasion (p<0.01). The histological type was not associated with the nodal status (p=0.52). Only twelve of 176 patients (6.8%) had low-grade endometrioid carcinoma, tumor size ≤2 cm and <50% myometrial infiltration.

Conclusions: The omission of lymphadenectomy based on the histological type, grade, tumor size and depth of myometrial invasion is not likely to have a large impact on the surgical treatment of endometrial cancer in our population because most patients present with large and advanced tumors. New strategies are proposed that prioritize hysterectomy performed in a general hospital as soon as possible after diagnosis, followed by an evaluation of the need for lymph node dissection at a reference center.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498149PMC
http://dx.doi.org/10.6061/clinics/2015(07)02DOI Listing

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