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Ablation of Long Noncoding RNA Hoxb3os Exacerbates Cystogenesis in Mouse Polycystic Kidney Disease.
J Am Soc Nephrol
January 2024
Department of Medicine, Stony Brook University, Stony Brook, New York.
Significance Statement: Long noncoding RNAs (lncRNAs) are a class of nonprotein coding RNAs with pivotal functions in development and disease. They have emerged as an exciting new drug target category for many common conditions. However, the role of lncRNAs in autosomal dominant polycystic kidney disease (ADPKD) has been understudied.
View Article and Find Full Text PDFWireless Communication Between Paired Leadless Pacemakers for Dual-Chamber Synchrony.
Circ Arrhythm Electrophysiol
July 2022
Academic Medical Center, Amsterdam, the Netherlands (R.E.K.).
Background: Leadless pacemakers (LPs) can mitigate conventional pacemaker complications related to the transvenous leads and subcutaneous pocket surrounding the pulse generator. Although single-chamber leadless pacing has been established, multichamber pacing requires wireless bidirectional communication across multiple LPs to maintain synchrony. This preclinical study demonstrates the chronic performance of implant-to-implant (i2i) communication that achieves synchronous, dual-chamber pacing with 2 LPs.
View Article and Find Full Text PDFPreclinical safety and electrical performance of novel atrial leadless pacemaker with dual-helix fixation.
Heart Rhythm
May 2022
Academic Medical Center, Amsterdam, The Netherlands.
Background: Complications associated with transvenous pacemakers, specifically those involving the lead or subcutaneous pocket, may be avoided with leadless pacemakers (LPs). The safety and efficacy of single-chamber right ventricular LPs have been demonstrated, but their right atrium (RA) use poses new design constraints.
Objectives: The purpose of this study was to evaluate the implant success, electrical performance, and safety of a novel RA LP design in benchtop and preclinical studies.
Implementation of a care bundle improves the management of patients with non-alcoholic fatty liver disease.
Frontline Gastroenterol
January 2021
Liver Unit, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK.
Background: Non-alcoholic fatty liver disease (NAFLD) is common and is associated with liver-related and cardiovascular-related morbidity. Our aims were: (1) to review the current management of patients with NAFLD attending hospital clinics in North East England (NEE) and assess the variability in care; (2) develop a NAFLD 'care bundle' to standardise care; (3) to assess the impact of implementation of the NAFLD care bundle.
Methods: A retrospective review was conducted to determine baseline management of patients with NAFLD attending seven hospitals in NEE.
Activation of SGK1.1 Upregulates the M-current in the Presence of Epilepsy Mutations.
Front Mol Neurosci
November 2021
Departamento de Ciencias Medicas Basicas and Instituto de Tecnologias Biomedicas, Universidad de La Laguna, San Cristóbal de La Laguna, Spain.
In the central nervous system, the M-current plays a critical role in regulating subthreshold electrical excitability of neurons, determining their firing properties and responsiveness to synaptic input. The M-channel is mainly formed by subunits Kv7.2 and Kv7.
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