Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511310 | PMC |
| http://dx.doi.org/10.1111/jdi.12297 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Young Athlete With Hypertension and Hypokalemia.
Hypertension
November 2024
Department of Nephrology, INSERM EnVI U1096, CHU Rouen, CIC-CRB 1404 (D.G.), University of Rouen Normandy, France.
We describe a 17-year-old woman diagnosed with severe hypertension during routine follow-up after the prescription of a combined oral contraceptive pill. Initially, due to her age, the estradiol-containing contraception, and high-level sport practice, physicians suspected drug-induced hypertension. Blood tests showed hypokalemia, and further investigations revealed pseudoaldosteronism.
View Article and Find Full Text PDF3--18-Glycyrrhetinic Acid or Its Glucuronide, the Metabolites of Glycyrrhizinic Acid with Individual Differences, Correlated with Diagnostic Marker for Licorice-Induced Pseudoaldosteronism in Humans.
Drug Metab Dispos
November 2024
Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-Dori, Mizuho-ku, Nagoya, Japan (R.S., K.I., Y.T., T.M.); Center for Kampo Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan (T.Y., K.F., K.W.); Department of Japanese Oriental (Kampo) Medicine, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan (T.N.); Department of Japanese Traditional (Kampo) Medicine, Kanazawa University Hospital, 13-1 Takaramachi, Kanazawa-City, Ishikawa, Japan (K.O.-O.); Kampo Clinical Center, Hiroshima University Hospital, 1-2-3, Kasumi, Minami-ku, Hiroshima, Japan (K.O.-O.); Department of Oriental Medicine, Kameda Medical Center, 929 Higashi-cho, Kamogawa, Chiba, Japan (K.M.); Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan (K.F.)
Article Synopsis
- Licorice is commonly used in traditional Japanese medicine and as a sweetener, but it can cause a side effect known as pseudoaldosteronism (PsA), which leads to symptoms like low potassium, high blood pressure, and fluid retention.
- A study examined 78 patients using Kampo medicines with licorice, finding multiple glycyrrhizinic acid metabolites in their blood and urine, including some newly identified ones.
- Individual differences were noted in the levels of these metabolites, suggesting they may influence susceptibility to PsA, with specific metabolites like 3--GA and 3-GA30G potentially playing a significant role.
Torsade de Pointes Caused by a Compound Licorice Tablet.
Int Heart J
July 2024
Department of Cardiology, Affiliated Hospital of Hebei University.
The clinical manifestations of licorice-induced pseudoaldosteronism include muscle weakness, periodic paralysis, hypokalemia, and hypertension. Excessive licorice consumption can lead to adverse reactions affecting multiple systems, including the endocrine, cardiovascular, nervous, digestive, and immune systems. Although licorice is a frequently used Chinese herbal medicine, life-threatening adverse reactions have been reported among its users.
View Article and Find Full Text PDFAnalysis of clinical factors associated with Kampo formula-induced pseudoaldosteronism based on self-reported information from the Japanese Adverse Drug Event Report database.
PLoS One
January 2024
Department of Kampo Medicine, Aizu Medical Center, Fukushima Medical University, Fukushima, Aizuwakamatsu, Japan.
Article Synopsis
- Drug-induced pseudoaldosteronism can occur as an adverse effect of Kampo formulas, with a study analyzing reports from the Japanese Adverse Drug Event Report database showing specific risk factors.
- The research identified 210 reports of pseudoaldosteronism among 6334 adverse event reports related to Kampo formulas, with a high prevalence in older females.
- Key associated factors included older age, female sex, low body weight, diuretic use, hypertension, and dementia, along with the dosage and duration of Glycyrrhiza, which is often included in these formulas.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!