AI Article Synopsis
- The study investigates the connection between CYP2J2 gene variations and the occurrence of ischemic stroke (IS) in a Chinese Han population.
- A case-control study involved 300 stroke patients and 300 healthy individuals, revealing that the GT genotype of the G-50T polymorphism in CYP2J2 is linked to a higher risk of IS.
- The findings suggest that this genetic variation may contribute to increased stroke risk among the Chinese population, with noted statistical significance even after accounting for other factors.
Article Abstract
Objective: The present study aims to investigate the relationship between CYP2J2 gene polymorphisms and ischemic stroke (IS) in a Chinese Han population.
Methods: We performed a case-control study including 300 stroke patients and 300 healthy control subjects to compare the distribution of genetic polymorphism G-50T in CYP2J2 gene.
Results: We found GT genotype of G-50T in CYP2J2 gene was associated with the risk for IS (13.7% vs. 7.7%, P = 0.037). After adjustment of confounders, the difference remains significant (OR = 1.890, 95% CI: 1.042-3.011).
Conclusion: CYP2J2 gene polymorphism might increase the risk of stroke in Chinese population.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509331 | PMC |
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