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Development and validation of a portable device for lab-free versatile nucleic acid extraction.
Biotechniques
October 2024
Department of Biomedical Engineering, Pennsylvania State University, University Park, PA, USA.
Nucleic acid testing (NAT) has revolutionized diagnostics by providing precise, rapid, and scalable detection methods for diverse biological samples. These recent advancements satisfy the increasing demand for on-site diagnostics, yet sample preparation remains a significant bottleneck for achieving highly sensitive diagnostic assays. There is an unmet need for compatible, efficient, and lab-free sample preparation for point-of-care NAT.
View Article and Find Full Text PDFAnti-cancer activity of zinc-tetraphenylporphyrin photosensitizer/dextran--polyacrylamide copolymer/Au(Ag) nanoparticle nanohybrids.
RSC Adv
February 2024
R.E. Kavetsky Institute for Experimental Pathology, Oncology and Radiobiology 45 Vasylkivska Str. 03022 Kyiv Ukraine.
A comparative study of anti-cancer photodynamic activities of three-component zinc-tetraphenylporphyrin photosensitizer/dextran--polyacrylamide copolymer/Au(Ag) nanoparticle (ZnTPP/D--PAA/Au(Ag)NP) nanohybrids on LNCaP prostate cancer cells was carried out under 420 nm light irradiation with low power. A significant cytotoxic effect was revealed for both ZnTPP/D--PAA/AgNP and ZnTPP/D--PAA/AuNP nanohybrids, where ZnTPP/D--PAA/AgNP nanohybrids exhibited considerably higher anticancer activity (82%) compared to ZnTPP/D--PAA/AuNP nanohybrids (45%). The higher activity of silver-containing nanohybrids is rationalized based on two factors.
View Article and Find Full Text PDFGiant tunnelling electroresistance in atomic-scale ferroelectric tunnel junctions.
Nat Commun
January 2024
University of Michigan-Shanghai Jiao Tong University Joint Institute, Shanghai Jiao Tong University, Shanghai, 200240, China.
Ferroelectric tunnel junctions are promising towards high-reliability and low-power non-volatile memories and computing devices. Yet it is challenging to maintain a high tunnelling electroresistance when the ferroelectric layer is thinned down towards atomic scale because of the ferroelectric structural instability and large depolarization field. Here we report ferroelectric tunnel junctions based on samarium-substituted layered bismuth oxide, which can maintain tunnelling electroresistance of 7 × 10 with the samarium-substituted bismuth oxide film down to one nanometer, three orders of magnitude higher than previous reports with such thickness, owing to efficient barrier modulation by the large ferroelectric polarization.
View Article and Find Full Text PDFHigh-Performance Monolithic 3D Integrated Complementary Inverters Based on Monolayer n-MoS and p-WSe.
Small
April 2024
Department of Materials Science and Engineering, National Tsing-Hua University, Hsinchu, 30013, Taiwan.
Herein, the structure of integrated M3D inverters are successfully demonstrated where a chemical vapor deposition (CVD) synthesized monolayer WSe p-type nanosheet FET is vertically integrated on top of CVD synthesized monolayer MoS n-type film FET arrays (2.5 × 2.5 cm) by semiconductor industry techniques, such as transfer, e-beam evaporation (EBV), and plasma etching processes.
View Article and Find Full Text PDFReducing False Alarms in Wearable Seizure Detection With EEGformer: A Compact Transformer Model for MCUs.
IEEE Trans Biomed Circuits Syst
June 2024
The long-term, continuous analysis of electroencephalography (EEG) signals on wearable devices to automatically detect seizures in epileptic patients is a high-potential application field for deep neural networks, and specifically for transformers, which are highly suited for end-to-end time series processing without handcrafted feature extraction. In this work, we propose a small-scale transformer detector, the EEGformer, compatible with unobtrusive acquisition setups that use only the temporal channels. EEGformer is the result of a hardware-oriented design exploration, aiming for efficient execution on tiny low-power micro-controller units (MCUs) and low latency and false alarm rate to increase patient and caregiver acceptance.
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