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This case report covers a patient presenting unconscious to the emergency department with a serum glucose level of 125.6 mmol/L and an associated hyperglycemia-induced hyponatremia with a sodium level of 101 mmol/L. The glucose level is, to our knowledge, one of the most extreme values described in medical literature.

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Hyperglycemia-induced hyponatremia: Reevaluation of the Na correction factor.

J Crit Care

December 2017

Dept. of Pharmacology, Physiology and Neuroscience, Univ. of South Carolina, Columbia, SC 29209, 8 Yaupon Way, Oak Island, NC 28465, United States. Electronic address:

This study addresses the clinically important relationship between the decreases in plasma Na and the increases in plasma glucose concentrations seen in diabetes and other hyperglycemic syndromes. This plasma 'Na correction factor', is generally accepted as 1.6mM Na per 100mg% glucose (0.

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