Lymphocytic infundibulo-neurohypophysitis is an uncommon inflammatory disorder postulated to be autoimmune in origin. Because of the location of inflammation, it selectively affects the posterior lobe of the pituitary (neurohypophysis) and pituitary stalk (infundibulum). The most common presentation is central diabetes insipidus. Although the definitive diagnosis is established histologically by a pituitary biopsy, radiological imaging can be valuable in diagnosing this condition. In this paper, we provide an overview of the pathophysiology, investigations, management, and outcomes of lymphocytic infundibulo-neurohypophysitis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s12020-015-0707-6 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A case of central diabetes insipidus after COVID-19 as a probable diagnosis of lymphocytic infundibulo-neurohypophysitis with positive anti-rabphilin-3A antibodies with review of literature.
Endocr J
December 2024
Department of Metabolism, Endocrinology and Molecular Medicine, Osaka Metropolitan University Graduate School of Medicine, Osaka 545-8585, Japan.
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2, and various complications have been reported. Furthermore, there have been increasing reports of endocrinopathy related to COVID-19 following the pandemic. We report a 49-year-old healthy woman who developed rapid onset of polydipsia and polyuria three weeks after COVID-19.
View Article and Find Full Text PDFArginine vasopressin deficiency onset after COVID-19 vaccination with positive anti-rabphilin-3A antibodies: a case report and literature review.
BMC Endocr Disord
August 2024
Department of Metabolism & Endocrinology, Juntendo University Graduate School, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Background: Arginine vasopressin deficiency (AVP-D) can occur due to various conditions, so clarifying its cause is important for deciding treatment strategy. Although several cases of AVP-D following coronavirus disease 2019(COVID-19) infection or COVID-19 vaccination have been reported, the diagnosis of the underlying disease has not been reported in most cases.
Case Presentation: A 75-year-old woman who presented with polydipsia and polyuria 9 weeks after contracting COVID-19 and 5 weeks after receiving the SARS-CoV-2 vaccination, leading to the final diagnosis of AVP-D 8 months after the first appearance of symptoms.
A Pregnant Woman with Excess Vasopressinase-Induced Diabetes Insipidus Complicated by Central Diabetes Insipidus like Lymphocytic Infundibulo-Neurohypophysitis.
Case Rep Endocrinol
April 2024
Department of Endocrinology and Diabetes, Saitama Medical University, 38 Morohongo, Moroyama, Iruma, Saitama 350-0495, Japan.
Article Synopsis
- A 39-year-old pregnant woman developed symptoms of gestational diabetes insipidus (DI) after 31 weeks, characterized by excessive thirst and urination, leading to the suspicion of DI based on lab results.
- Her condition worsened, resulting in acute kidney failure and an emergency cesarean section at 34 weeks, revealing a significantly enlarged placenta.
- Post-delivery, she received a treatment that resolved her symptoms, and findings indicated that the excessive vasopressinase from the enlarged placenta, along with insufficient vasopressin from the pituitary, contributed to her DI symptoms.
A Case of Lymphocytic Infundibulo-neurohypophysitis Exhibiting Spontaneous Regression.
JCEM Case Rep
March 2023
Department of Diabetes and Endocrinology, Medical Research Institute, Kitano Hospital, PIIF Tazuke-Kofukai, Kita-ku, Osaka 530-8480, Japan.
Lymphocytic infundibulo-neurohypophysitis (LINH) is a rare autoimmune inflammatory process that selectively affects the neurohypophysis and the pituitary stalk, typically presenting with central diabetes insipidus (CDI). LINH is considered underdiagnosed because the definitive diagnosis requires invasive pituitary surgery with a high risk of complications. We present a case of CDI resulting from LINH, which was treated with conservative management, eschewing both glucocorticoid treatment and pituitary surgery.
View Article and Find Full Text PDFTwo children with lymphocytic hypophysitis presenting with positive anti-rabphilin-3A antibody.
Endocr J
July 2023
Department of Neurosurgery, Kumamoto University Hospital, Kumamoto 860-8556, Japan.
Lymphocytic hypophysitis (LYH) is a rare chronic inflammatory disease characterized by lymphocytic infiltration of the anterior or posterior pituitary gland and hypothalamus. LYH is subdivided into lymphocytic adenohypophysitis (LAH), lymphocytic infundibulo-neurohypophysitis (LINH), and lymphocytic panhypophysitis (LPH) depending on the primary site. Most cases occur in adults, with few cases reported in children, and it is especially important to distinguish LYH from suprasellar malignancies, such as germ cell tumors and other neoplastic diseases.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!