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Serum specific vasopressin-degrading activity is related to blood total cholesterol levels in men but not in women.
Med Chem
July 2012
Experimental and Clinical Physiopathology Research Group, Department of Health Sciences, Faculty of Experimental and Health Sciences, University of Jaén, Jaén, Spain.
The role of vasopressin (AVP) in the pathophysiology of cardiovascular disease is controversial, but this peptide hormone is elevated in heart failure and some forms of hypertension. Also, AVP has vasoconstrictor, mitogenic, hyperplasic and renal fluid retaining properties which, by analogy with angiotensin II, may have deleterious effects when present in chronic excess. Furthermore, cholesterol blood levels are also associated with hypertension, although the underlying mechanism is not known.
View Article and Find Full Text PDFActivity of cystylaminopeptidase (CAP) was established repeatedly in the blood serum of 40 healthy women since the 14th to the 37th week of pregnancy by means of method using S-benzyl-L-cystein-p-nitranilid as substrate. Continuous increase of values was observed, more moderate up to the 28th week, later sheerer, with a certain dispersion in examination of different women in the same length of pregnancy. No statistically significant dependency was found out by evaluating different influences on the CAP activity (weight, length, and sex of the infant, time of gestation and age of mother at delivery).
View Article and Find Full Text PDFChange in plasma cystyl aminopeptidase (oxytocinase) between 30-34 weeks' gestation as a predictor of pregnancy-induced hypertension.
Obstet Gynecol
December 1988
Department of Obstetrics and Gynecology, University of Leicester, England.
Ninety-two primigravidas were screened biweekly by measurement of plasma cystyl aminopeptidase from 28 weeks' gestation until delivery. Fourteen developed hypertension with or without proteinuria after 36 weeks. The hypertensive group had significantly higher levels of the enzyme at 30 weeks, although this difference was not significant at 34 weeks.
View Article and Find Full Text PDFA study of investigations used to predict outcome of pregnancy after threatened abortion.
Br J Obstet Gynaecol
March 1980
Sixty-nine patients who presented with threatened abortion had a number of investigations aimed at providing information with which to predict pregnancy outcome. Ultrasound examination, and measurement of plasma oestradiol and progesterone levels were all significantly more accurate in predicting the pregnancy outcome than clinical examination. Measurements of plasma levels of beta 1-glycoprotein, alpha fetoprotein (AFP), beta subunit human chorionic gonadotrophin (hCG), cystyl aminopeptidase, and human placental lactogen (hPL) also appeared better than clinical examination but the differences did not reach statistical significance while measurement of hCG levels in early morning urine were less accurate than clinical examination.
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