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Temporal evolution of the distribution of hepatitis E virus genotypes in Southwestern France. | LitMetric

Temporal evolution of the distribution of hepatitis E virus genotypes in Southwestern France.

Infect Genet Evol

INSERM, UMR1043, Toulouse F-31300, France; Department of Virology, National Reference Center for Hepatitis E Virus, CHU Purpan, Toulouse F-31300, France; Université Paul Sabatier, Toulouse, France. Electronic address:

Published: October 2015

AI Article Synopsis

  • Southwest France, particularly the Midi-Pyrénées, is a key area for hepatitis E virus (HEV), with a study focusing on HEV strains from 2003 to 2014 to compare local and national trends.
  • The research analyzed the ORF1 and ORF2 regions of the HEV genome, revealing a decrease in subgenotype 3f and an increase in subgenotype 3c over time in the Midi-Pyrénées, while overall strain distribution mirrored that of the entire country.
  • The study suggests that local dietary habits may contribute to the higher seroprevalence of HEV in the Midi-Pyrénées, rather than specific circulating variants of the virus.

Article Abstract

Southwest France is a highly endemic region for hepatitis E virus (HEV). This study examined the circulation of HEV strains between 2003 and 2014 in the Midi-Pyrénées, and compared these data with those from the rest of France. The polyproline region (PPR) of the ORF1 region of the HEV genome was also analyzed. HEV genotype was determined by sequencing a 348-nt fragment within the ORF2 gene for 333 strains in the Midi-Pyrénées and for 571 strains from the rest of France. PPR region was characterized for 56 strains. The frequency of subgenotype 3f decreased over time, whereas subgenotype 3c increased in the Midi-Pyrénées. Repartition of strains did not differ in the Midi-Pyrénées compared to the rest of France. HEV3i and HEV4 have been recently detected throughout France. PPR lengths showed that two major groups of HEV3f exist. Our study shows that HEV3 distribution in the Midi-Pyrénées was similar to the whole of France. Local dietary habits could explain the higher seroprevalence in the Midi-Pyrénées rather the circulation of a particular variant in this region.

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Source
http://dx.doi.org/10.1016/j.meegid.2015.07.028DOI Listing

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